Single-Molecule Dendrimer-Hydrocarbon Interaction

dc.contributor.author Pasupathy, Karthikeyan
dc.contributor.author Lamm, Monica
dc.contributor.author Suek, Nicholas
dc.contributor.author Lyons, John
dc.contributor.author Ching, Justin
dc.contributor.author Jones, Aaron
dc.contributor.author Lu, Qi
dc.contributor.author Lamm, Monica
dc.contributor.author Ke, Pu Chun
dc.contributor.department Chemical and Biological Engineering
dc.date 2018-02-15T18:22:32.000
dc.date.accessioned 2020-06-30T01:08:16Z
dc.date.available 2020-06-30T01:08:16Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2008
dc.date.embargo 2015-01-20
dc.date.issued 2008-01-01
dc.description.abstract <p>We report our single-molecule fluorescence microscopy and molecular dynamics simulation studies on the interaction of poly(amidoamine) dendrimer and squalane hydrocarbon in aqueous solution. Our spectrophotometry measurements indicate that this interaction increases with the pH of the solvent. Our simulations show that squalane resides primarily on the perimeter of the dendrimer at low to neutral pH, but becomes encapsulated by the dendrimer at high pH. Using single-molecule fluorescence microscopy, we have identified that the binding between PAMAM and squalane is reversible. At a pH value of 8, the approaching, binding, and characteristic times of a single fluorescently-labeled dendrimer to squalane are 0.5 s, 7.5 s, and 0.5 s, respectively. Both our spectrophotometry measurements and simulations show that the interaction between PAMAM and squalane is stronger for lower generation dendrimers. This study facilitates our understanding of using dendritic and hyperbranched polymers for gas hydrate prevention in the petroleum industry.</p>
dc.description.comments <p>This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/cbe_pubs/186/
dc.identifier.articleid 1181
dc.identifier.contextkey 6543751
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath cbe_pubs/186
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/13275
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/cbe_pubs/186/2008_LammMH_SingleMoleculeDendrimer.pdf|||Fri Jan 14 21:44:26 UTC 2022
dc.source.uri 10.2174/1874140100802010047
dc.subject.disciplines Biochemical and Biomolecular Engineering
dc.subject.disciplines Biological and Chemical Physics
dc.subject.disciplines Chemical Engineering
dc.subject.disciplines Physics
dc.subject.keywords PAMAM
dc.subject.keywords hydrocarbon
dc.subject.keywords TIRF
dc.title Single-Molecule Dendrimer-Hydrocarbon Interaction
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 17142bdc-ab55-46f0-8f9d-ad2cb338deb7
relation.isOrgUnitOfPublication 86545861-382c-4c15-8c52-eb8e9afe6b75
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