A novel virus in swine is closely related to the human hepatitis E virus

dc.contributor.author Meng, Xiang-Jin
dc.contributor.author Haynes, Joseph
dc.contributor.author Purcell, Robert
dc.contributor.author Halbur, Patrick
dc.contributor.author Lehman, James
dc.contributor.author Webb, Dale
dc.contributor.author Tsareva, Tatiana
dc.contributor.author Haynes, Joseph
dc.contributor.author Thacker, Brad
dc.contributor.author Emerson, Suzanne
dc.contributor.department Veterinary Pathology
dc.date 2018-02-18T23:36:04.000
dc.date.accessioned 2020-07-07T05:16:14Z
dc.date.available 2020-07-07T05:16:14Z
dc.date.issued 1997-09-01
dc.description.abstract <p>A novel virus, designated swine hepatitis E virus (swine HEV), was identified in pigs. Swine HEV crossreacts with antibody to the human HEV capsid antigen. Swine HEV is a ubiquitous agent and the majority of swine ≥3 months of age in herds from the midwestern United States were seropositive. Young pigs naturally infected by swine HEV were clinically normal but had microscopic evidence of hepatitis, and developed viremia prior to seroconversion. The entire ORFs 2 and 3 were amplified by reverse transcription–PCR from sera of naturally infected pigs. The putative capsid gene (ORF2) of swine HEV shared about 79–80% sequence identity at the nucleotide level and 90–92% identity at the amino acid level with human HEV strains. The small ORF3 of swine HEV had 83–85% nucleotide sequence identity and 77–82% amino acid identity with human HEV strains. Phylogenetic analyses showed that swine HEV is closely related to, but distinct from, human HEV strains. The discovery of swine HEV not only has implications for HEV vaccine development, diagnosis, and biology, but also raises a potential public health concern for zoonosis or xenozoonosis following xenotransplantation with pig organs.</p>
dc.description.comments <p>This article is published as Meng, Xiang-Jin, Robert H. Purcell, Patrick G. Halbur, James R. Lehman, Dale M. Webb, Tatiana S. Tsareva, Joseph S. Haynes, Brad J. Thacker, and Suzanne U. Emerson. "A novel virus in swine is closely related to the human hepatitis E virus." Proceedings of the National Academy of Sciences 94, no. 18 (1997): 9860-9865. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vpath_pubs/92/
dc.identifier.articleid 1095
dc.identifier.contextkey 10868951
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vpath_pubs/92
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92522
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vpath_pubs/92/1997_Haynes_NovelVirus.pdf|||Sat Jan 15 02:29:50 UTC 2022
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title A novel virus in swine is closely related to the human hepatitis E virus
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 8c426a1b-1e25-4efc-9283-518a1a6522ed
relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
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