Persistent Colonization of Sheep by Escherichia coli O157:H7 and Other E. coli Pathotypes

dc.contributor.author Cornick, Nancy
dc.contributor.author Booher, Sheridan
dc.contributor.author Cornick, Nancy
dc.contributor.author Casey, T. A.
dc.contributor.author Moon, Harley
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-17T09:56:38.000
dc.date.accessioned 2020-07-07T05:15:35Z
dc.date.available 2020-07-07T05:15:35Z
dc.date.issued 2000-11-01
dc.description.abstract <p>Shiga toxin-producing <em>Escherichia coli</em> (STEC) is an important cause of food-borne illness in humans. Ruminants appear to be more frequently colonized by STEC than are other animals, but the reason(s) for this is unknown. We compared the frequency, magnitude, duration, and transmissibility of colonization of sheep by <em>E. coli</em> O157:H7 to that by other pathotypes of <em>E. coli</em>. Young adult sheep were simultaneously inoculated with a cocktail consisting of two strains of <em>E. coli</em>O157:H7, two strains of enterotoxigenic <em>E. coli</em> (ETEC), and one strain of enteropathogenic <em>E. coli</em>. Both STEC strains and ETEC 2041 were given at either 10<sup>7</sup> or 10<sup>10</sup>CFU/strain/animal. The other strains were given only at 10<sup>10</sup>CFU/strain. We found no consistent differences among pathotypes in the frequency, magnitude, and transmissibility of colonization. However, the STEC strains tended to persist to 2 weeks and 2 months postinoculation more frequently than did the other pathotypes. The tendency for persistence of the STEC strains was apparent following an inoculation dose of either 10<sup>7</sup> or 10<sup>10</sup> CFU. One of the ETEC strains also persisted when inoculated at 10<sup>10</sup> CFU. However, in contrast to the STEC strains, it did not persist when inoculated at 10<sup>7</sup> CFU. These results support the hypothesis that STEC is better adapted to persist in the alimentary tracts of sheep than are other pathotypes of<em>E. coli</em>.</p>
dc.description.comments <p>This article is from <em>Applied and Environmental Microbiology</em> 66 (2000): 4926, doi:<a href="http://dx.doi.org/10.1128/AEM.66.11.4926-4934.2000" target="_blank">10.1128/AEM.66.11.4926-4934.2000</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/98/
dc.identifier.articleid 1103
dc.identifier.contextkey 7983336
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/98
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92408
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/98/2000_Cornick_PersistentColonization.pdf|||Sat Jan 15 02:37:47 UTC 2022
dc.source.uri 10.1128/AEM.66.11.4926-4934.2000
dc.subject.disciplines Veterinary Medicine
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Persistent Colonization of Sheep by Escherichia coli O157:H7 and Other E. coli Pathotypes
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication a89b8fad-4329-4bb1-bbcd-c1d3b324f0f7
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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