Associations Between Multidrug Resistance, Plasmid Content, and Virulence Potential Among Extraintestinal Pathogenic and Commensal Escherichia coli from Humans and Poultry

dc.contributor.author Johnson, Timothy
dc.contributor.author Nolan, Lisa
dc.contributor.author Logue, Catherine
dc.contributor.author Johnson, James
dc.contributor.author Kuskowski, Michael
dc.contributor.author Sherwood, Julie
dc.contributor.author Barnes, H.
dc.contributor.author DebRoy, Chitrita
dc.contributor.author Wannemuehler, Yvonne
dc.contributor.author Obata-Yasuoka, Mana
dc.contributor.author Spanjaard, Lodewijk
dc.contributor.author Nolan, Lisa
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-13T10:39:25.000
dc.date.accessioned 2020-07-07T05:15:08Z
dc.date.available 2020-07-07T05:15:08Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2012
dc.date.embargo 2013-05-06
dc.date.issued 2012-01-04
dc.description.abstract <p>The emergence of plasmid-mediated multidrug resistance (MDR) among enteric bacteria presents a serious challenge to the treatment of bacterial infections in humans and animals. Recent studies suggest that avian<em>Escherichia coli</em> commonly possess the ability to resist multiple antimicrobial agents, and might serve as reservoirs of MDR for human extraintestinal pathogenic <em>Escherichia coli</em> (ExPEC) and commensal <em>E. coli</em> populations. We determined antimicrobial susceptibility profiles for 2202 human and avian <em>E. coli</em> isolates, then sought for associations among resistance profile, plasmid content, virulence factor profile, and phylogenetic group. Avian-source isolates harbored greater proportions of MDR than their human counterparts, and avian ExPEC had higher proportions of MDR than did avian commensal <em>E. coli</em>. MDR was significantly associated with possession of the IncA/C, IncP1-α, IncF, and IncI1 plasmid types. Overall, inferred virulence potential did not correlate with drug susceptibility phenotype. However, certain virulence genes were positively associated with MDR, including <em>ireA</em>,<em>ibeA</em>, <em>fyuA</em>, <em>cvaC</em>, <em>iss</em>, <em>iutA</em>, <em>iha</em>, and <em>afa</em>. According to the total dataset, isolates segregated significantly according to host species and clinical status, thus suggesting that avian and human ExPEC and commensal <em>E. coli</em> represent four distinct populations with limited overlap. These findings suggest that in extraintestinal <em>E. coli</em>, MDR is most commonly associated with plasmids, and that these plasmids are frequently found among avian-source <em>E. coli</em> from poultry production systems.</p>
dc.description.comments <p>This is a copy of an article published in <em>Foodborne Pathogens and Disease </em>© 2012 Mary Ann Liebert, Inc; <em>Foodborne Pathogens and Disease</em> is available online at <a href="http://online.liebertpub.com/" target="_blank">http://online.liebertpub.com</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/33/
dc.identifier.articleid 1030
dc.identifier.contextkey 4111525
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/33
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92337
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/33/2012_JohnsonTJ_AssociationsBetweenMultidrug.pdf|||Fri Jan 14 23:37:18 UTC 2022
dc.source.uri 10.1089/fpd.2011.0961
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Associations Between Multidrug Resistance, Plasmid Content, and Virulence Potential Among Extraintestinal Pathogenic and Commensal Escherichia coli from Humans and Poultry
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 9e7506b4-e945-47cf-9195-e814dac6c9fd
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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