Livestock Models in Translational Medicine Roth, James Tuggle, Christopher Roth, James
dc.contributor.department Veterinary Microbiology and Preventive Medicine 2018-02-17T04:48:08.000 2020-07-07T05:15:23Z 2020-07-07T05:15:23Z Thu Jan 01 00:00:00 UTC 2015 2015-01-01
dc.description.abstract <p>This issue of the <em>ILAR Journal</em> focuses on livestock models in translational medicine. Livestock models of selected human diseases present important advantages as compared with rodent models for translating fundamental breakthroughs in biology to useful preventatives and therapeutics for humans. Livestock reflect the complexity of applying medical advances in an outbred species. In many cases, the pathogenesis of infectious, metabolic, genetic, and neoplastic diseases in livestock species more closely resembles that in humans than does the pathogenesis of rodent models. Livestock models also provide the advantage of similar organ size and function and the ability to serially sample an animal throughout the study period. Research using livestock models for human disease often benefits not only human health but animal health and food production as well. This issue of the <em>ILAR Journal</em> presents information on translational research using livestock models in two broad areas: microbiology and infectious disease (transmissible spongiform encephalopathies, mycobacterial infections, influenza A virus infection, vaccine development and testing, the human microbiota) and metabolic, neoplastic, and genetic disorders (stem cell therapy, male germ line cell biology, pulmonary adenocarcinoma, muscular dystrophy, wound healing). In addition, there is a manuscript devoted to Institutional Animal Care and Use Committees’ responsibilities for reviewing research using livestock models. Conducting translational research using livestock models requires special facilities and researchers with expertise in livestock. There are many institutions in the world with experienced researchers and facilities designed for livestock research; primarily associated with colleges of agriculture and veterinary medicine or government laboratories.</p>
dc.description.comments <p>This article is from <em>ILAR Journal</em> 56 (2015): 1, doi:<a href="" target="_blank">10.1093/ilar/ilv011</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/
dc.identifier.articleid 1087
dc.identifier.contextkey 7793978
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/72
dc.language.iso en
dc.source.bitstream archive/|||Sat Jan 15 01:44:00 UTC 2022
dc.source.uri 10.1093/ilar/ilv011
dc.subject.disciplines Genomics
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Translational Medical Research
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords cattle
dc.subject.keywords genetic diseases
dc.subject.keywords genomics
dc.subject.keywords infectious diseases
dc.subject.keywords metabolic diseases
dc.subject.keywords sheep
dc.subject.keywords swine
dc.subject.keywords translational medical research
dc.title Livestock Models in Translational Medicine
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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