Uncovering genetic factors that mark subtypes of retinal ganglion cells

dc.contributor.author Maldonado, Gabriel
dc.contributor.department Genetics, Developmental and Cell Biology
dc.date 2018-02-18T16:49:33.000
dc.date.accessioned 2020-07-07T05:12:04Z
dc.date.available 2020-07-07T05:12:04Z
dc.date.issued 2017-04-11
dc.description.abstract <p>Glaucoma, the second leading cause of blindness, is characterized by the death of ganglion cells in the retina. Ganglion cells serve as the final output neurons of the retina by gathering information and relaying it to the visual centers of the brain. It is estimated that there are at least 30 functionally distinct types of these cells in the retina; however, this is believed to be an underestimate as many of the types are rare and uncharacterized. Our lab has used single cell analyses to identify mRNAs expressed in different retinal ganglion cell types, following classification based on their morphology, function, or fluorescent protein expression. My project aims to characterize some of the candidate genetic factors identified in these analyses and asks whether they are, in fact, confined to a single type of retinal ganglion cell. Specifically, I examined gene expression using in situ hybridization on sections of mature retinal tissue. My results have revealed several genes expressed in subsets of retinal ganglion cells. However, it has proven challenging to identify factors expressed in just a single ganglion cell type and further detailed expression analysis will be necessary to determine whether they could be used to designate a specific ganglion cell subtype.</p>
dc.identifier archive/lib.dr.iastate.edu/undergradresearch_symposium/2017/presentations/85/
dc.identifier.articleid 1265
dc.identifier.contextkey 10453744
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath undergradresearch_symposium/2017/presentations/85
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91854
dc.relation.ispartofseries Symposium on Undergraduate Research and Creative Expression
dc.source.bitstream archive/lib.dr.iastate.edu/undergradresearch_symposium/2017/presentations/85/Session_20IV.C.3_Maldonado.pptx|||Sat Jan 15 02:12:35 UTC 2022
dc.subject.disciplines Genetics
dc.title Uncovering genetic factors that mark subtypes of retinal ganglion cells
dc.type event
dc.type.genre event
dspace.entity.type Publication
relation.isSeriesOfPublication 6730f354-97b8-4408-bad3-7e5c3b2fca9d
thesis.degree.discipline Biology
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