Narrative review of therapies for chronic enteropathies in dogs and cats

dc.contributor.author Makielski, Kelly
dc.contributor.author Cullen, Jonah
dc.contributor.author O'Connor, Annette
dc.contributor.author O'Connor, Annette
dc.contributor.author Jergens, Albert
dc.contributor.department Veterinary Clinical Sciences
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date 2018-12-15T08:55:07.000
dc.date.accessioned 2020-07-07T05:12:45Z
dc.date.available 2020-07-07T05:12:45Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2018
dc.date.issued 2018-01-01
dc.description.abstract <p><strong>Background </strong>The optimal medical treatment for chronic enteropathy (CE) in dogs and cats is controversial. Sequential treatment using diet, antimicrobials, and immunosuppressive drugs is the most common strategy used by clinicians.</p> <p><strong>Objectives </strong>To review the evidence for the effectiveness of dietary, drug, and alternative health interventions for inducing clinical remission in dogs and cats with CE.</p> <p><strong>Animals </strong>Retrospective study of dogs and cats with a diagnosis of chronic enteropathy.</p> <p><strong>Methods </strong>MEDLINE and Centre for Agriculture and Bioscience International (CABI) databases (1950 to March 2017) were searched for randomized controlled trials (RCTs), observational studies, and case series. The primary outcome was induction of clinical remission. All studies were evaluated using the quality of evidence grading guidelines (I‐IV), which assign a score defining the strength and quality of the evidence.</p> <p><strong>Results </strong>Twenty‐two studies (11 RCTs in dogs and 2 in cats and 9 cohort studies or case series) met the inclusion criteria for inducing remission of gastrointestinal (GI) signs. Of the 13 RCTs achieving grade I scores, 10 studies (totaling 218 dogs and 65 cats) compared single treatment: diet (n = 3), immunosuppressives (n = 3), antimicrobials (n = 2), anti‐inflammatory drugs (n = 1), and probiotics (n = 1). Three case series (grade III) reported clinical remission using an elimination diet fed to 55 cats and use of enrofloxacin to induce remission in dogs with granulomatous colitis (2 studies totaling 16 dogs).</p> <p><strong>Conclusions and Clinical Importance </strong>The current evidence for treatment of CE is much greater in dogs than in cats. There is sufficient strong evidence to recommend the use of therapeutic GI diets, glucocorticoids, enrofloxacin, or some combination of these in dogs with CE. Therapeutic GI diets and glucocorticoids are most useful in cats with CE.</p>
dc.description.comments <p>This article is published as Makielski, Kelly, Jonah Cullen, Annette O'Connor, and Albert E. Jergens. "Narrative review of therapies for chronic enteropathies in dogs and cats." <em>Journal of Veterinary Internal Medicine</em> (2018). DOI: <a href="https://dx.doi.org/10.1111/jvim.15345" target="_blank">10.1111/jvim.15345</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vdpam_pubs/127/
dc.identifier.articleid 1130
dc.identifier.contextkey 13461864
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vdpam_pubs/127
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/91969
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vdpam_pubs/127/2018_OConnor_NarrativeReview.pdf|||Fri Jan 14 19:28:05 UTC 2022
dc.source.uri 10.1111/jvim.15345
dc.subject.disciplines Internal Medicine
dc.subject.disciplines Small or Companion Animal Medicine
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords antibiotics
dc.subject.keywords cyclosporine
dc.subject.keywords diet
dc.subject.keywords drug treatment
dc.subject.keywords immunosuppressives
dc.subject.keywords inflammatory bowel disease
dc.subject.keywords prednisone
dc.subject.keywords quality of evidence guidelines
dc.subject.keywords randomized controlled trial
dc.title Narrative review of therapies for chronic enteropathies in dogs and cats
dc.type article
dc.type.genre article
dspace.entity.type Publication
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