Metal-catalyzed and aryne-mediated multicomponent approaches to heterocycles

Date
2012-01-01
Authors
Markina, Nataliya
Major Professor
Advisor
Richard C. Larock
Thomas J. Greenbowe
Committee Member
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Altmetrics
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Research Projects
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Chemistry
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Chemistry
Abstract

Over the course of the work described in this dissertation, several novel methodologies have been successfully developed and applied to the synthesis of medicinally-relevant heterocycles, including indoles, benzo[b]furans, 1,2-dihydroisoquinolines, 1H-indazoles, and pyrido[1,2-a]indoles. In these methods, well-studied transition metal-catalyzed processes and newly discovered aryne-mediated processes have been found applicable and efficient when applied to the synthesis of a variety of heterocycles. Most of these processes have also been transformed into multicomponent processes.

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