Over the last decades, organic synthesis has played an essential role in the pharmaceutical industry. The development of synthetic methodologies and strategies allow us to access complex natural products in an efficient way and fuel the drug discovery. Chapter one describes the study of aryl triflates and aryl pivalates reactions with electrophiles and provides extensive information about the regioselectivities of the reactions. Chapter two introduces a novel method to generate 6- and 8-substituted 1-methoxynaphthalene (or alpha-naphthol). Chapter three describes synthetic studies toward eurycolactone C.