FEM simulation of ion transport in a muliplex nanopore biosensor
Date
2023-08
Authors
Yaseen, Anas
Major Professor
Advisor
Shotriya, Pranav
Ganapathysubramanian, Baskar
Nilsen-Hamilton, Marit
Committee Member
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Abstract
With the rise in demand for point-of-care diagnostics, the rise of biosensing technology has been instrumental in meeting said demand. Out of the many trends in biosensing technology, the most promising one is multi-detection and nanotechnology. Nanotechnology shows lots of promise in being implemented in wearable devices that can continuously monitor human health. Implementing multi-sensing technology into nanotechnology can allow for cheaper wearable devices by reducing the number of biosensors within the device. One method of sensing that has promising results is the use of ion-based transport nanopores manufactured from Aluminum Oxide due to their low cost and high sensitivity. Understanding the effects of ion transport is critical in assisting in designing optimized nanoporous biosensors.
The key focus of this study is to study the effects of ion transport in a multiplexed nanoporous biosensor to better understand how to design and build these sensors. This project builds on previous work done by Sivranjani has done in simulating these sensors. In this work, we have successfully generated meshes for multiplexed nanoporous biosensors with different DNA-aptamers. These meshes include mixed nanopores and nanopores with empty channels to study the effects of modified and unmodified nanopores as well as introducing channels with only Aluminum Oxide. However, we have been unable to successfully model the impedances of these sensors due to not having the capabilities of modeling the EIS and DRT utilizing large data With the rise in demand for point-of-care diagnostics, the rise of biosensing technology has been instrumental in meeting said demand. Out of the many trends in biosensing technology, the most promising one is multi-detection and nanotechnology. Nanotechnology shows lots of promise in being implemented in wearable devices that can continuously monitor human health. Implementing multi-sensing technology into nanotechnology can allow for cheaper wearable devices by reducing the number of biosensors within the device. One method of sensing that has promising results is the use of ion-based transport nanopores manufactured from Aluminum Oxide due to their low cost and high sensitivity. Understanding the effects of ion transport is critical in assisting in designing optimized nanoporous biosensors.
The key focus of this study is to study the effects of ion transport in a multiplexed nanoporous biosensor to better understand how to design and build these sensors. This project builds on previous work done by Sivranjani has done in simulating these sensors. In this work, we have successfully generated meshes for multiplexed nanoporous biosensors with different DNA-aptamers. These meshes include mixed nanopores and nanopores with empty channels to study the effects of modified and unmodified nanopores as well as introducing channels with only Aluminum Oxide. However, we have been unable to successfully model the impedances of these sensors due to not having the capabilities of modeling the EIS and DRT utilizing large data
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