Proposed multidimensional pain outcome methodology to demonstrate analgesic drug efficacy and facilitate future drug approval for piglet castration

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Baysinger, Angela
Webb, Sherrie R.
Brown, Jennifer
Coetzee, Johann F.
Crawford, Sara
DeDecker, Ashley
Pairis-Garcia, Monique
Sutherland, Mhairi A.
Viscardi, Abbie V.
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Cambridge University Press
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Veterinary Diagnostic and Production Animal Medicine
Castration of male piglets in the United States is conducted without analgesics because no Food and Drug Administration (FDA) approved products are labeled for pain control in swine. The absence of approved products is primarily due to a wide variation in how pain is measured in suckling piglets and the lack of validated pain-specific outcomes individually indistinct from other biological responses, such as general stress or inflammation responses with cortisol. Simply put, to measure pain mitigation, measurement of pain must be specific, quantifiable, and defined. Therefore, given the need for mitigating castration pain, a consortium of researchers, veterinarians, industry, and regulatory agencies was formed to identify potential animal-based outcomes and develop a methodology, based on the known scientific research, to measure pain and the efficacy of mitigation strategies. The outcome-based measures included physiological, neuroendocrine, behavioral, and production parameters. Ultimately, this consortium aims to provide a validated multimodal methodology to demonstrate analgesic drug efficacy for piglet castration. Measurable outcomes were selected based on published studies suggesting their validity, reliability, and sensitivity for the direct or indirect measurement of pain associated with surgical castration in piglets. Outcomes to be considered are observation of pain behaviors (i.e. ethogram defined behaviors and piglet grimace scale), gait parameters measured with a pressure mat, infrared thermography of skin temperature of the cranium and periphery of the eye, and blood biomarkers. Other measures include body weight and mortality rate. This standardized measurement of the outcome variable's primary goal is to facilitate consistency and rigor by developing a research methodology utilizing endpoints that are well-defined and reliably measure pain in piglets. The resulting methodology will facilitate and guide the evaluation of the effectiveness of comprehensive analgesic interventions for 3- to 5-day-old piglets following surgical castration.
This article has been published by Cambridge University Press as Baysinger, Angela, Sherrie R. Webb, Jennifer Brown, Johann F. Coetzee, Sara Crawford, Ashley DeDecker, Locke A. Karriker, Monique Pairis-Garcia, Mhairi A. Sutherland, and Abbie V. Viscardi. "Proposed multidimensional pain outcome methodology to demonstrate analgesic drug efficacy and facilitate future drug approval for piglet castration." Animal Health Research Reviews (2021): 1-14. DOI: 10.1017/S1466252321000141. Copyright 2021 The Authors. Attribution 4.0 International (CC BY 4.0). Posted with permission.
piglet, pain, castration, biomarkers, endpoints, mitigation