Proposed multidimensional pain outcome methodology to demonstrate analgesic drug efficacy and facilitate future drug approval for piglet castration

dc.contributor.author Baysinger, Angela
dc.contributor.author Webb, Sherrie R.
dc.contributor.author Brown, Jennifer
dc.contributor.author Coetzee, Johann F.
dc.contributor.author Crawford, Sara
dc.contributor.author DeDecker, Ashley
dc.contributor.author Pairis-Garcia, Monique
dc.contributor.author Sutherland, Mhairi A.
dc.contributor.author Viscardi, Abbie V.
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date.accessioned 2022-01-06T18:04:59Z
dc.date.available 2022-01-06T18:04:59Z
dc.date.issued 2021-12-03
dc.description.abstract Castration of male piglets in the United States is conducted without analgesics because no Food and Drug Administration (FDA) approved products are labeled for pain control in swine. The absence of approved products is primarily due to a wide variation in how pain is measured in suckling piglets and the lack of validated pain-specific outcomes individually indistinct from other biological responses, such as general stress or inflammation responses with cortisol. Simply put, to measure pain mitigation, measurement of pain must be specific, quantifiable, and defined. Therefore, given the need for mitigating castration pain, a consortium of researchers, veterinarians, industry, and regulatory agencies was formed to identify potential animal-based outcomes and develop a methodology, based on the known scientific research, to measure pain and the efficacy of mitigation strategies. The outcome-based measures included physiological, neuroendocrine, behavioral, and production parameters. Ultimately, this consortium aims to provide a validated multimodal methodology to demonstrate analgesic drug efficacy for piglet castration. Measurable outcomes were selected based on published studies suggesting their validity, reliability, and sensitivity for the direct or indirect measurement of pain associated with surgical castration in piglets. Outcomes to be considered are observation of pain behaviors (i.e. ethogram defined behaviors and piglet grimace scale), gait parameters measured with a pressure mat, infrared thermography of skin temperature of the cranium and periphery of the eye, and blood biomarkers. Other measures include body weight and mortality rate. This standardized measurement of the outcome variable's primary goal is to facilitate consistency and rigor by developing a research methodology utilizing endpoints that are well-defined and reliably measure pain in piglets. The resulting methodology will facilitate and guide the evaluation of the effectiveness of comprehensive analgesic interventions for 3- to 5-day-old piglets following surgical castration.
dc.description.comments This article has been published by Cambridge University Press as Baysinger, Angela, Sherrie R. Webb, Jennifer Brown, Johann F. Coetzee, Sara Crawford, Ashley DeDecker, Locke A. Karriker, Monique Pairis-Garcia, Mhairi A. Sutherland, and Abbie V. Viscardi. "Proposed multidimensional pain outcome methodology to demonstrate analgesic drug efficacy and facilitate future drug approval for piglet castration." Animal Health Research Reviews (2021): 1-14. DOI: 10.1017/S1466252321000141. Copyright 2021 The Authors. Attribution 4.0 International (CC BY 4.0). Posted with permission.
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/JvNVXN9v
dc.language.iso en_US
dc.publisher Cambridge University Press
dc.source.uri https://doi.org/10.1017/S1466252321000141 *
dc.subject piglet
dc.subject pain
dc.subject castration
dc.subject biomarkers
dc.subject endpoints
dc.subject mitigation
dc.subject.disciplines DegreeDisciplines::Medicine and Health Sciences::Veterinary Medicine::Large or Food Animal and Equine Medicine
dc.subject.disciplines DegreeDisciplines::Medicine and Health Sciences::Veterinary Medicine::Veterinary Toxicology and Pharmacology
dc.title Proposed multidimensional pain outcome methodology to demonstrate analgesic drug efficacy and facilitate future drug approval for piglet castration
dc.type Article
dspace.entity.type Publication
relation.isAuthorOfPublication cdddf686-265a-41eb-9374-c5ff25e5120d
relation.isOrgUnitOfPublication 5ab07352-4171-4f53-bbd7-ac5d616f7aa8
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