Randomized Clinical Trial to Evaluate the Pathogenicity of Bibersteinia trehalosi in Respiratory Disease among Calves

Date
2014-04-01
Authors
Plummer, Paul
Hanthorn, Christy
Dewell, Grant
Dewell, Reneé
Cooper, Vickie
Frana, Timothy
Plummer, Paul
Wang, Chong
Dewell, Grant
Wang, Chong
Major Professor
Advisor
Committee Member
Journal Title
Journal ISSN
Volume Title
Publisher
Altmetrics
Authors
Research Projects
Organizational Units
Journal Issue
Series
Department
StatisticsVeterinary Microbiology and Preventive MedicineVeterinary Diagnostic and Production Animal Medicine
Abstract

Bibersteinia trehalosi causes respiratory disease in ruminants particularly in wild and domestic sheep. Recently, there has been an increased number of B. trehalosi isolates obtained from diagnostic samples from bovine respiratory disease cases. This study evaluated the role of B. trehalosi in bovine respiratory disease using an intra-tracheal inoculation model in calves. Thirty six cross bred 2–3 month old dairy calves were inoculated intra-tracheally with either leukotoxin negative B. trehalosi, leukotoxin positive B. trehalosi isolate, Mannheimia haemolytica, a combination of leukotoxin negative B. trehalosi and M. haemolytica or negative control. Calves were euthanized and necropsy performed on day 10 of study. B. trehalosi inoculated calves did not have increased lung involvement compared to control calves. Additionally, B. trehalosiwas only cultured once from the lungs of inoculated calves at necropsy. Based on these findings B. trehalosi may not be a primary pathogen of respiratory disease in cattle. Culture of B. trehalosifrom diagnostic submissions should not be immediately identified as a primary cause of respiratory disease.

Comments

This article is from BMC Veterinary Research 10 (2014): 89, doi:10.1186/1746-6148-10-89. Posted with permission.

Description
Keywords
Citation
DOI
Collections