Cryptosporidium Parvum-Induced Inflammatory Bowel Disease of TCR-β- x TCR-δ-Deficient Mice

dc.contributor.author Waters, W. Ray
dc.contributor.author Haynes, Joseph
dc.contributor.author Wannemeuhler, Michael
dc.contributor.author Sacco, Randy
dc.contributor.author Palmer, Mitchell
dc.contributor.author Haynes, Joseph
dc.contributor.author Pesch, Bruce
dc.contributor.author Harp, James
dc.contributor.department Veterinary Pathology
dc.date 2018-02-18T23:36:48.000
dc.date.accessioned 2020-07-07T05:16:14Z
dc.date.available 2020-07-07T05:16:14Z
dc.date.issued 1999-12-01
dc.description.abstract <p>Experimental inoculation of neonatal immunocompetent strains of mice with Cryptosporidium parvum results in a transient, noninflammatory enteric infection. In the present study, we show that inoculation of mice deficient in a 3 and y8 T cells (TCR-3- X TCR-8-deficient mice) with C. parvum results in persistent infection and severe inflammatory bowel disease- like lesions. The most severe lesions in these mice were in the cecum with similar yet less severe lesions in the ileum and proximal colon. The most notable aspect of the histopathology was glandular hyperplasia with abscess formation, extensive fibrosis of the lamina propria with infiltrates of predominately polymorphonuclear cells and macrophages, and a few small aggregates of B cells. Persistently infected mice also developed extensive hepatic periportal fibrosis in association with C. parvum colonization of bile ducts. Lesions observed in TCR- 3- X TCR-8-deficient mice were markedly different than previously described lesions detected in C. parvum-infected TCR-o-deficient mice. Cryptosporidium parvum-infected TCR-o-deficient mice have extensive infiltrations of B cells, whereas TCR-P3- X TCR-8-deficient mice had only a few small aggregates of B cells. These findings indicate that although y8 T cells are not necessary for induction of intestinal inflammation in C. parvum-infected o(4 T- cell-deficient mice, their presence does alter the morphology of the ensuing lesion.</p>
dc.description.comments <p>This article is published as Waters, W. Ray, Michael J. Wannemuehler, Randy E. Sacco, Mitchell V. Palmer, Joseph S. Haynes, Bruce A. Pesch, and James A. Harp. "Cryptosporidium parvum-induced inflammatory bowel disease of TCR-β-x TCR-δ-deficient mice." The Journal of parasitology (1999): 1100-1105. <a href="http://dx.doi.org/10.1145" target="_blank">10.2307/3285674</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vpath_pubs/94/
dc.identifier.articleid 1097
dc.identifier.contextkey 10879368
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vpath_pubs/94
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92524
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vpath_pubs/94/1999_Haynes_CryptosporidiumParvumInduced.pdf|||Sat Jan 15 02:32:39 UTC 2022
dc.source.uri 10.2307/3285674
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Cryptosporidium Parvum-Induced Inflammatory Bowel Disease of TCR-β- x TCR-δ-Deficient Mice
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 8c426a1b-1e25-4efc-9283-518a1a6522ed
relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
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