In this study the objective was to determine whether use of vaccination against Actinobacillus pleuropneumoniae (APP) had an effect on the antimicrobial consumption in finisher pigs, when compared to herds without vaccination. Based on observational data, we found that the change in antimicrobial consumption after vaccination was initiated was significant associated with the baseline antimicrobial use before vaccination. The decrease in antimicrobial used was more pronounced in vaccinated herds (N=101) when compared to herds without vaccination (N=320), indicating an effect of vaccination against APP on the antimicrobial consumption level.