Information systems (IS) are essential to the modern-day organization. Unfortunately, many organizations often select an IS that does not optimally match organizational needs and requirements. The mismatch between organizational requirements and an implemented IS often results in a loss of productivity, efficiency, and company morale. One way to address this problem is undertaking a formal IS evaluation process; however, IS evaluation requires complex-multidimensional approaches that present many challenges. Moreover, research literature that could inform the design and conduct of such evaluations is limited. This paper aims to fill the gap in the existing literature by introducing a novel IS Evaluation Framework to guide organizations in the IS selection process.