Alterations in bovine neutrophil function during the periparturient period
Neutrophils from 8 Holstein heifers were evaluated for function during the periparturient period. Random migration, ingestion of bacteria, superoxide anion production, native (nonenhanced) chemiluminescence, iodination, and antibody-dependent, cell-mediated cytotoxicity by neutrophils were determined. Foremilk samples were evaluated for bacteria. Significant (P < 0.05) increases in random migration of neutrophils, iodination, and chemiluminescence were evident 2 weeks before parturition and then decreased dramatically by the frrst week after parturition. These impairments of neutrophil function after parturition may be manifested as a severe cumulative deficit in the native defenses afforded by the neutrophil.
This article is published as Kehrli, M.E., B.J. Nonnecke, and J.A. Roth. 1989. Alterations in bovine neutrophil function during the periparturient period. Am J Vet Res, 50:207-214.