Alterations in bovine neutrophil function during the periparturient period

Date
1989-02-01
Authors
Kehrli, Marcus
Nonnecke, Brian
Roth, James
Roth, James
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Roth, James
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Veterinary Microbiology and Preventive Medicine
Abstract

Neutrophils from 8 Holstein heifers were evaluated for function during the periparturient period. Random migration, ingestion of bacteria, superoxide anion production, native (nonenhanced) chemiluminescence, iodination, and antibody-dependent, cell-mediated cytotoxicity by neutrophils were determined. Foremilk samples were evaluated for bacteria. Significant (P < 0.05) increases in random migration of neutrophils, iodination, and chemiluminescence were evident 2 weeks before parturition and then decreased dramatically by the frrst week after parturition. These impairments of neutrophil function after parturition may be manifested as a severe cumulative deficit in the native defenses afforded by the neutrophil.

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This article is published as Kehrli, M.E., B.J. Nonnecke, and J.A. Roth. 1989. Alterations in bovine neutrophil function during the periparturient period. Am J Vet Res, 50:207-214.

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