Osteopenic Disease in Growing Pigs: Diagnostic Methods Using Serum and Urine Calcium and Phosphorus Values, Parathormone Assay, and Bone Analysis

dc.contributor.author Hagemoser, Wayne
dc.contributor.author Goff, Jesse
dc.contributor.author Haynes, Joseph
dc.contributor.author Sanderson, Thomas
dc.contributor.author Haynes, Joseph
dc.contributor.department Veterinary Pathology
dc.date 2018-02-18T23:36:55.000
dc.date.accessioned 2020-07-07T05:16:15Z
dc.date.available 2020-07-07T05:16:15Z
dc.date.issued 2000-11-01
dc.description.abstract <p>This research was performed to evaluate the utility of several serum and urine parameters as well as bone ash and plasma parathormone assay to diagnose and monitor diet-related osteopenia in growing pigs. Five diets were tested as follows: calcium-deficient, phosphorus-replete; moderate-deficiency of calcium and phosphorus; marked deficiency of calcium and phosphorus; calcium replete, phosphorus deficient; and vitamin D deficient. Parameters monitored included serum calcium and phosphorus as well as ratios of urine calcium to creatinine, phosphorus to creatinine, calcium to phosphorus, and percent fractional excretions of calcium and phosphorus. Plasma parathormone (PTH) levels were monitored in 2 of 3 experiments. Osteopenic bone differences at necropsy were evaluated by bone density, percent ash, ash per milliliter bone, calcium per milliliter bone, and phosphorus per milliliter bone. Marked change in urine mineral parameters, especially the calcium-to-phosphorus ratio, typically occurred within 1 to 2 days of treatment and preceded significant change in serum mineral or plasma PTH by 2 to 3 weeks. When monitored, plasma PTH levels were elevated following treatment, which confirms the hyperparathyroid state induced by the test diets. Significant differences in bone mineralization between control and treatment diets at necropsy were generally observed. The results of this study indicate that the analysis of urine minerals offers an early, noninvasive technique to investigate diet-associated osteopenic disease in growing pigs, which can be supported further by bone mineral analysis at postmortem using techniques herein described. Several urine mineral reference intervals for application to field investigations are included. Research into application of similar techniques to evaluate calcium and phosphorus homeostasis in pigs of all ages, including gestating and lactating gilts and sows, appears warranted.</p>
dc.description.comments <p>This article is published as Hagemoser, Wayne A., Jesse P. Goff, Thomas P. Sanderson, and Joseph S. Haynes. "Osteopenic disease in growing pigs: diagnostic methods using serum and urine calcium and phosphorus values, parathormone assay, and bone analysis." Journal of veterinary diagnostic investigation 12, no. 6 (2000): 525-534. doi: <a href="https://doi.org/10.1177/104063870001200606">10.1177/104063870001200606</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vpath_pubs/95/
dc.identifier.articleid 1098
dc.identifier.contextkey 10879480
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vpath_pubs/95
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92525
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vpath_pubs/95/2000_Haynes_OsteopenicDisease.pdf|||Sat Jan 15 02:34:03 UTC 2022
dc.source.uri 10.1177/104063870001200606
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Medicine
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.title Osteopenic Disease in Growing Pigs: Diagnostic Methods Using Serum and Urine Calcium and Phosphorus Values, Parathormone Assay, and Bone Analysis
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 8c426a1b-1e25-4efc-9283-518a1a6522ed
relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
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