Causative Gene Discovery for Sheep Inherited Disorders

dc.contributor.author Zhao, Xia
dc.contributor.author Onteru, Suneel
dc.contributor.author Rothschild, Max
dc.contributor.author Rothschild, Max
dc.contributor.author Garrick, Dorian
dc.date 2018-08-25T19:01:16.000
dc.date.accessioned 2020-06-29T23:33:21Z
dc.date.available 2020-06-29T23:33:21Z
dc.date.copyright Sat Jan 01 00:00:00 UTC 2011
dc.date.issued 2011-01-01
dc.description.abstract <p>Chondrodysplasia, inherited rickets and lower motor neuron disease are three sheep disorders in New Zealand that have been recently shown to be inherited apparently in a recessive manner. To discover the causative genes involved in the above diseases, around 50,000 genetic differences called single nucleotide polymorphisms (SNPs) throughout the genome were tested to define homozygous regions, one of which should harbor the causative mutation. Fine mapping of these regions for each disease was performed by discovering new SNPs located on candidate genes in these regions. To date, responsible mutations were successfully identified for inherited rickets and lower motor neuron disease. Our findings will benefit sheep breeding practices by providing a tool that can be used to avoid atrisk mating and may benefit science by providing animal disease models for human studies.</p>
dc.identifier archive/lib.dr.iastate.edu/ans_air/vol657/iss1/49/
dc.identifier.articleid 1664
dc.identifier.contextkey 3399611
dc.identifier.doi https://doi.org/10.31274/ans_air-180814-678
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_air/vol657/iss1/49
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/8796
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.source.bitstream archive/lib.dr.iastate.edu/ans_air/vol657/iss1/49/R2625.pdf|||Sat Jan 15 00:28:57 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.keywords ASL R2625
dc.title Causative Gene Discovery for Sheep Inherited Disorders
dc.type article
dc.type.genre sheep
dspace.entity.type Publication
relation.isAuthorOfPublication a5915699-0c8a-411e-a601-1564d7090ab9
relation.isJournalIssueOfPublication 16ba5fcb-7135-4998-951b-bf17e9c33730
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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