A selectin inhibitor decreases neutrophil infiltration during acute Mannheimia haemolytica pneumonia

dc.contributor.author Gallup, Jack
dc.contributor.author Radi, Zaher
dc.contributor.author Brogden, Kim
dc.contributor.author Dixon, Richard
dc.contributor.author Ackermann, Mark
dc.contributor.author Gallup, Jack
dc.contributor.author Ackermann, Mark
dc.contributor.department Veterinary Pathology
dc.date 2018-02-13T06:25:12.000
dc.date.accessioned 2020-07-07T05:15:52Z
dc.date.available 2020-07-07T05:15:52Z
dc.date.embargo 2013-02-26
dc.date.issued 2002-11-01
dc.description.abstract <p>The degree to which the selectin inhibitor TBC1269 reduces neutrophil infiltration in specific microscopic locations of the lung during acute pneumonia of neonates was determined. Neonatal calves were inoculated intrabronchially with <em>Mannheimia (Pasteurella) haemolytica</em> or saline, and lung tissue was collected at 2 and 6 hours postinoculation (PI). One 6-hour group inoculated with <em>M. haemolytica</em> received TBC1269 intravenously before and after inoculation with <em>M. haemolytica</em>. Infiltrates of neutrophils were significantly higher in the alveolar lumen and septae but lower in the bronchial lumen and epithelium at 6 hours PI than at 2 hours PI. Significantly fewer neutrophils (<em>P</em> > 0.05) were present in the alveolar lumen and septae, and the bronchiolar lumen and lamina propria in the lungs of TBC1269-treated calves compared with untreated calves at 6 hours PI. TBC1269 did not alter the infiltration into bronchi and blood vessels or the expression of the selectin-independent adhesion molecule, ICAM-1. This work suggests that during acute pneumonia of neonates 1) neutrophil infiltrates progressively increase in the alveolar lumens and septae but decrease in the bronchial lumen and epithelium with time, 2) TBC1269 reduces neutrophil infiltration into specific regions of alveoli and bronchioles rather than uniformly throughout the lung, and 3) selectin inhibition does not affect the location and intensity of ICAM-1 expression.</p>
dc.description.comments <p>This article is from <em>Veterinary Pathology</em>, 39, no. 6 (November 2002): 697–705, doi:<a href="http://dx.doi.org/10.1354/vp.39-6-697" target="_blank">10.1354/vp.39-6-697</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vpath_pubs/36/
dc.identifier.articleid 1037
dc.identifier.contextkey 3790792
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vpath_pubs/36
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92460
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vpath_pubs/36/2002_SelectinInhibitorDecreases.pdf|||Fri Jan 14 23:46:07 UTC 2022
dc.source.uri 10.1354/vp.39-6-697
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.keywords Adhesion molecules
dc.subject.keywords ICAM-1
dc.subject.keywords Mannheimeia haemolytica
dc.subject.keywords Selectins
dc.subject.keywords Shipping fever
dc.title A selectin inhibitor decreases neutrophil infiltration during acute Mannheimia haemolytica pneumonia
dc.type article
dc.type.genre article
dspace.entity.type Publication
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relation.isAuthorOfPublication 86c1ed73-b60d-48ce-8f35-449bc320a693
relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
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