Erysipelothrix rhusiopathiae: Association of Spa-type with Serotype and Role in Protective Immunity Ingebritson, Alaina Roth, James Roth, James Hauer, Paul
dc.contributor.department Veterinary Microbiology and Preventive Medicine 2018-02-17T04:45:43.000 2020-07-07T05:15:30Z 2020-07-07T05:15:30Z 2010-03-01
dc.description.abstract <p>A collection of swine, fish, and cetacean <em>Erysipelothrix rhusiopathiae</em> strains representing 16 serotypes was analyzed for possession of the three currently recognized surface protective antigen (spa)-types: spaA, spaB, and spaC. Polymerase chain reaction (PCR) assays and Western blotting with a SpaA-specific monoclonal antibody demonstrated that spa-type is not confined to specific serotype groups. In particular, the spa-type of strains of aquatic origin was more variable than those of terrestrial origin, and possessed the distinct ability to express more than one spa. In a cross-protection study, mice immunized with an <em>E. rhusiopathiae</em> serotype 2 SpaA-type strain and challenged with various <em>E. rhusiopathiae</em> isolates were completely protected against strains exhibiting a single homologous spa, but variably protected against strains possessing a heterologous spa or those harboring more than one spa-type.</p>
dc.description.comments <p>This article is from <em>Vaccine</em> 28, 2490, doi:<a href="" id="x-ddDoi" target="_blank">10.1016/j.vaccine.2010.01.041</a>.</p>
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dc.identifier archive/
dc.identifier.articleid 1072
dc.identifier.contextkey 7792338
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/87
dc.language.iso en
dc.source.bitstream archive/|||Sat Jan 15 02:15:29 UTC 2022
dc.source.uri 10.1016/j.vaccine.2010.01.041
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords Erysipelothrix rhusiopathiae
dc.subject.keywords Surface protective antigen
dc.subject.keywords Erysipelas
dc.title Erysipelothrix rhusiopathiae: Association of Spa-type with Serotype and Role in Protective Immunity
dc.type article
dc.type.genre article
dspace.entity.type Publication
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