Cutaneous Melanoma: A Comparative Study Between Gray Horses, Canines, and Humans
Cutaneous melanoma affects multiple species, including gray horses, dogs, and humans. It is typically aggressive in dogs and humans, and more benign in gray horses. Although developmentally different (gray horse melanoma is frequently genetically inherited, while human and canine melanoma is usually acquired), treatment of gray horse, canine, and human cutaneous melanoma is similar. Treatment usually starts with surgical removal, but the best adjuvant treatment is unknown. As additional research is needed to define the best combination treatment approach for all three species, the similarities between them mean they can be translational models for each other. The similarities, differences, and translational opportunities between gray horse, canine, and human melanoma will be explored in the following review.