Praziquantel Resistance in the Zoonotic Cestode Dipylidium caninum
dc.contributor.author | Jesudoss Chelladurai, Jeba | |
dc.contributor.author | Brewer, Matt | |
dc.contributor.author | Kifleyohannes, Tsegabirhan | |
dc.contributor.author | Scott, Janelle | |
dc.contributor.author | Brewer, Matthew | |
dc.contributor.department | Veterinary Pathology | |
dc.date | 2019-08-11T17:13:53.000 | |
dc.date.accessioned | 2020-07-07T05:15:42Z | |
dc.date.available | 2020-07-07T05:15:42Z | |
dc.date.copyright | Mon Jan 01 00:00:00 UTC 2018 | |
dc.date.issued | 2018-11-07 | |
dc.description.abstract | <p><em>Dipylidium caninum</em> is a cosmopolitan cestode infecting dogs, cats, and humans. Praziquantel is a highly effective cestocidal drug and resistance in adult cestodes has not been reported. From 2016 to 2018, a population of dogs with cestode infections that could not be eliminated despite multiple treatments with praziquantel or epsiprantel was identified. Cases of <em>D. caninum</em> were clinically resistant to praziquantel and could not be resolved despite increasing the dose, frequency, and duration of treatment. Resistant isolates were identified and characterized by sequencing the 28S, 12S, and voltage-gated calcium channel beta subunit genes. Cases were only resolved following treatment with nitroscanate or a compounded pyrantel/praziquantel/oxantel product. Clinicians should be aware of this alarming development as treatment options for cestodes are limited in both human and veterinary medicine.</p> | |
dc.description.comments | <p>This article is published as Chelladurai, Jeba Jesudoss, Tsegabirhan Kifleyohannes, Janelle Scott, and Matthew T. Brewer. "Praziquantel Resistance in the Zoonotic Cestode Dipylidium caninum." <em>The American Journal of Tropical Medicine and Hygiene</em> 99, no. 5 (2018): 1201-1205. DOI: <a href="https://dx.doi.org/10.4269/ajtmh.18-0533" target="_blank">10.4269/ajtmh.18-0533</a>. Posted with permission.</p> | |
dc.format.mimetype | application/pdf | |
dc.identifier | archive/lib.dr.iastate.edu/vpath_pubs/105/ | |
dc.identifier.articleid | 1108 | |
dc.identifier.contextkey | 13486055 | |
dc.identifier.s3bucket | isulib-bepress-aws-west | |
dc.identifier.submissionpath | vpath_pubs/105 | |
dc.identifier.uri | https://dr.lib.iastate.edu/handle/20.500.12876/92429 | |
dc.language.iso | en | |
dc.source.bitstream | archive/lib.dr.iastate.edu/vpath_pubs/105/0-2018_BrewerMatthew_PraziquantelResistance_PermGrant.pdf|||Fri Jan 14 18:22:25 UTC 2022 | |
dc.source.bitstream | archive/lib.dr.iastate.edu/vpath_pubs/105/2018_Brewer_PraziquantelResistance.pdf|||Fri Jan 14 18:22:27 UTC 2022 | |
dc.source.uri | 10.4269/ajtmh.18-0533 | |
dc.subject.disciplines | Veterinary Pathology and Pathobiology | |
dc.subject.disciplines | Veterinary Preventive Medicine, Epidemiology, and Public Health | |
dc.subject.disciplines | Veterinary Toxicology and Pharmacology | |
dc.title | Praziquantel Resistance in the Zoonotic Cestode Dipylidium caninum | |
dc.type | article | |
dc.type.genre | article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 5da9e3cf-a247-450d-98e7-74c92c5ea8a9 | |
relation.isOrgUnitOfPublication | cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f |
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