Effect of Bovine Immunodeficiency-Like Virus Infection on Immune Function in Experimentally Infected Cattle

dc.contributor.author Flaming, Kevan
dc.contributor.author Van Der Maaten, Martin
dc.contributor.author Roth, James
dc.contributor.author Whetstone, Cecelia
dc.contributor.author Carpenter, Susan
dc.contributor.author Frank, Dagmar
dc.contributor.author Roth, James
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-17T04:42:57.000
dc.date.accessioned 2020-07-07T05:15:18Z
dc.date.available 2020-07-07T05:15:18Z
dc.date.issued 1993-03-01
dc.description.abstract <p>Bovine immunodeficiency-like virus (BIV) is a bovine lentivirus that has antigenic and genetic homology with the human immunodeficiency virus. Little work has been reported on the effect of BIV infection on bovine immune function. This study was designed to evaluate lymphocyte blastogenesis, mononuclear cell subset numbers, neutrophil function, hematology, and clinical signs in three groups of cattle. These groups were evaluated at 0–2 months post inoculation (PI, Group 1), 4–5 months PI (Group 2), or 19–27 months PI (Group 3). BIV infected animals were inoculated with the R-29 isolate of BIV in tissue culture cells, peripheral blood mononuclear cells from a R-29 infected calf, or a molecular clone of the R-29 isolate. Most inoculated animals seroconverted to BIV by Western immunoblot. BIV was reisolated from most of the animals inoculated. BIV infection was associated with an increase in the lymphocyte blastogenic response to the mitogen phytohemagglutinin in Groups 2 and 3. Neutrophil antibody dependent cell mediated cytotoxicity and neutrophil iodination were decreased (<em>P</em><0.05) in BIV infected cattle (Groups 2 and 3 and Group 3, respectively). All animals were clinically normal during the evaluation periods. Notable differences were not observed in the other assessments performed. Work with additional BIV isolates and over longer time frames is warranted.</p>
dc.description.comments <p>This article is from <em>Veterinary Immunology and Immunopathology</em> 36 (1993): 91, doi:<a href="http://dx.doi.org/10.1016/0165-2427(93)90100-I" id="x-doi-value" target="_blank" title=" ">10.1016/0165-2427(93)90100-I</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/62/
dc.identifier.articleid 1059
dc.identifier.contextkey 7790225
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/62
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92369
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/62/1993_Roth_EffectBovine.pdf|||Sat Jan 15 01:18:08 UTC 2022
dc.source.uri 10.1016/0165-2427(93)90100-I
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Medicine
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Effect of Bovine Immunodeficiency-Like Virus Infection on Immune Function in Experimentally Infected Cattle
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 909dd0b2-ec0a-41e2-b4e0-9e5ff76b7622
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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