Synthesis of oxaboranes via nickel-catalyzed dearylative cyclocondensation

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2022-05-20
Authors
Koeritz, Mason T.
Banovetz, Haley K.
Prell, Sean A.
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The Royal Society of Chemistry
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Chemistry
Abstract
We report Ni-catalyzed dearylative cyclocondensation of aldehydes, alkynes, and triphenylborane. The reaction is initiated by oxidative cyclization of the aldehyde and alkyne coupling partners to generate an oxanickelacyclopentene which reacts with triphenylborane to form oxaboranes. This formal dearylative cyclocondensation reaction generates oxaboranes in moderate-to-high yields (47–99%) with high regioselectivities under mild reaction conditions. This approach represents a direct and modular synthesis of oxaboranes which are difficult to access using current methods. These oxaboranes are readily transformed into valuable building blocks for organic synthesis and an additional class of boron heterocycles. Selective homocoupling forms oxaboroles, oxidation generates aldol products, and reduction and arylation form substituted allylic alcohols.
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This article is published as Koeritz, Mason T., Haley K. Banovetz, Sean A. Prell, and Levi M. Stanley. "Synthesis of oxaboranes via nickel-catalyzed dearylative cyclocondensation." Chemical Science 13, no. 26 (2022): 7790-7795. DOI: 10.1039/D2SC01840C. Copyright 2022 The Author(s). Attribution-NonCommercial 3.0 Unported (CC BY-NC 3.0). Posted with permission.
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