The evaluation of Mycobacterium tuberculosis complex species-specific antigens and purified protein derivatives for the detection of bovine tuberculosis using the interferon-gamma release assay

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2013-01-01
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Bass, Kristin
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W. Ray Waters
Jesse Hostetter
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Veterinary Pathology
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Mycobacterium bovis is the causative agent of tuberculosis in cattle and the most common organism isolated from cattle with tuberculosis. The broad host range, low infective dose, and presence of wildlife reservoirs make eradication and control of bovine tuberculosis difficult. Current eradication and control programs are in need of improved ante mortem diagnostic assays to detect M. bovis infection. The Interferon-gamma release assay is a rapid and reliable assay for bovine tuberculosis; however the presence of conserved antigens within the Mycobacterium genus as well as vaccination status of animals against M. bovis decreases the accuracy of the assay. Therefore, new antigens are needed that can distinguish infection from prior exposure to non-pathogenic mycobacteria as well as vaccinated animals. These antigens can then be incorporated into the Interferon-gamma release assay to increase its ability as a diagnostic tool.

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Tue Jan 01 00:00:00 UTC 2013