The evaluation of Mycobacterium tuberculosis complex species-specific antigens and purified protein derivatives for the detection of bovine tuberculosis using the interferon-gamma release assay

dc.contributor.advisor W. Ray Waters
dc.contributor.advisor Jesse Hostetter
dc.contributor.author Bass, Kristin
dc.contributor.department Veterinary Pathology
dc.date 2018-07-23T11:56:39.000
dc.date.accessioned 2020-06-30T02:49:23Z
dc.date.available 2020-06-30T02:49:23Z
dc.date.copyright Tue Jan 01 00:00:00 UTC 2013
dc.date.embargo 2015-07-30
dc.date.issued 2013-01-01
dc.description.abstract <p><em>Mycobacterium bovis</em> is the causative agent of tuberculosis in cattle and the most common organism isolated from cattle with tuberculosis. The broad host range, low infective dose, and presence of wildlife reservoirs make eradication and control of bovine tuberculosis difficult. Current eradication and control programs are in need of improved ante mortem diagnostic assays to detect <em>M. bovis</em> infection. The Interferon-gamma release assay is a rapid and reliable assay for bovine tuberculosis; however the presence of conserved antigens within the <em>Mycobacterium</em> genus as well as vaccination status of animals against <em>M. bovis</em> decreases the accuracy of the assay. Therefore, new antigens are needed that can distinguish infection from prior exposure to non-pathogenic mycobacteria as well as vaccinated animals. These antigens can then be incorporated into the Interferon-gamma release assay to increase its ability as a diagnostic tool.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/etd/13391/
dc.identifier.articleid 4398
dc.identifier.contextkey 4615895
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath etd/13391
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/27578
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/etd/13391/Bass_iastate_0097M_13741.pdf|||Fri Jan 14 19:51:16 UTC 2022
dc.subject.disciplines Allergy and Immunology
dc.subject.disciplines Immunology and Infectious Disease
dc.subject.disciplines Medical Immunology
dc.subject.keywords bovine tuberculosis
dc.subject.keywords Interferon-gamma
dc.subject.keywords MTBC-specific antigens
dc.subject.keywords Mycobacterium bovis
dc.title The evaluation of Mycobacterium tuberculosis complex species-specific antigens and purified protein derivatives for the detection of bovine tuberculosis using the interferon-gamma release assay
dc.type article
dc.type.genre thesis
dspace.entity.type Publication
relation.isOrgUnitOfPublication cf38d7e3-b5f8-4859-83e3-ae8fab6a4c5f
thesis.degree.level thesis
thesis.degree.name Master of Science
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