Metabolic engineering of biocatalysts for carboxylic acids production

dc.contributor.author Liu, Ping
dc.contributor.author Jarboe, Laura
dc.contributor.department Chemical and Biological Engineering
dc.date 2018-02-13T21:33:12.000
dc.date.accessioned 2020-06-30T01:10:52Z
dc.date.available 2020-06-30T01:10:52Z
dc.date.copyright Sun Jan 01 00:00:00 UTC 2012
dc.date.embargo 2014-02-17
dc.date.issued 2012-10-01
dc.description.abstract <p>Fermentation of renewable feedstocks by microbes to produce sustainable fuels and chemicals has the potential to replace petrochemical-based production. For example, carboxylic acids produced by microbial fermentation can be used to generate primary building blocks of industrial chemicals by either enzymatic or chemical catalysis. In order to achieve the titer, yield and productivity values required for economically viable processes, the carboxylic acid-producing microbes need to be robust and wellperforming. Traditional strain development methods based on mutagenesis have proven useful in the selection of desirable microbial behavior, such as robustness and carboxylic acid production. On the other hand, rationally-based metabolic engineering, like genetic manipulation for pathway design, has becoming increasingly important to this field and has been used for the production of several organic acids, such as succinic acid, malic acid and lactic acid. This review investigates recent works on Saccharomyces cerevisiae and Escherichia coli , as well as the strategies to improve tolerance towards these chemicals.</p>
dc.description.comments <p>This article is from <em>Computational and Structural Biotechnology</em> 3 (2012): e201210011, doi:<a href="http://dx.doi.org/10.5936/csbj.201210011" target="_blank">10.5936/csbj.201210011</a>.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/cbe_pubs/85/
dc.identifier.articleid 1082
dc.identifier.contextkey 5146095
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath cbe_pubs/85
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/13587
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/cbe_pubs/85/2012_LiuP_MetabolicEngineeringBiocatalysts.pdf|||Sat Jan 15 02:12:14 UTC 2022
dc.source.uri 10.5936/csbj.201210011
dc.subject.disciplines Biochemical and Biomolecular Engineering
dc.subject.disciplines Biological Engineering
dc.subject.disciplines Catalysis and Reaction Engineering
dc.subject.disciplines Oil, Gas, and Energy
dc.title Metabolic engineering of biocatalysts for carboxylic acids production
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 6113d68a-37ba-4092-8ed5-44d66391fae4
relation.isOrgUnitOfPublication 86545861-382c-4c15-8c52-eb8e9afe6b75
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