Comparison of two commercial ovine Campylobacter vaccines and an experimental bacterin in guinea pigs inoculated with Campylobacter jejuni

dc.contributor.author Plummer, Paul
dc.contributor.author Sahin, Orhan
dc.contributor.author Zhang, Qijing
dc.contributor.author DiVerde, Kevin
dc.contributor.author Zhang, Qijing
dc.contributor.author Yaeger, Michael
dc.contributor.department Veterinary Pathology
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date 2018-02-18T23:29:57.000
dc.date.accessioned 2020-07-07T05:14:48Z
dc.date.available 2020-07-07T05:14:48Z
dc.date.copyright Sat Jan 01 00:00:00 UTC 2011
dc.date.issued 2011-06-01
dc.description.abstract <p><strong>Objective</strong>—To compare efficacy of 2 commercial ovine <em>Campylobacter</em> vaccines and an experimental bacterin in guinea pigs following IP inoculation with <em>Campylobacter jejuni</em> IA3902.</p> <p><strong>Animals</strong>—51 female guinea pigs.</p> <p><strong>Procedures</strong>—Pregnant and nonpregnant animals were randomly assigned to 1 of 4 treatment groups and administered a commercial <em>Campylobacter</em> vaccine labeled for prevention of campylobacteriosis in sheep via two 5-mL doses 14 days apart (vaccine A; n = 13), another labeled for prevention of campylobacteriosis via two 2-mL doses (vaccine B; 12), an experimental bacterin prepared from the challenge strain (12), or a sham vaccine (14). Ten days later, animals were challenged IP with <em>C jejuni</em> IA3902; 48 hours later, animals were euthanized, complete necropsy was performed, and blood and tissue samples were obtained for bacteriologic culture.</p> <p><strong>Results</strong>—Administration of vaccine B or the experimental bacterin, but not vaccine A, significantly reduced 48-hour infection rates versus administration of the sham vaccine. A significantly reduced 48-hour infection rate was associated with administration of vaccine B independent of pregnancy status.</p> <p><strong>Conclusions and Clinical Relevance</strong>—Administration of vaccine B significantly reduced infection in guinea pigs challenged with <em>C jejuni</em> IA3902, similar to a homologous bacterin. Results suggested that vaccine B or an autogenous product may be effective in controlling ovine campylobacteriosis caused by this emergent abortifacient strain. Bacteriologic culture of blood, liver, bile, and uterus in nonpregnant guinea pigs 48 hours after inoculation may be a useful screening tool for comparing efficacy of <em>C jejuni</em> vaccines.</p>
dc.description.comments <p>This article is published as Burrough, Eric R., Orhan Sahin, Paul J. Plummer, Kevin D. DiVerde, Qijing Zhang, and Michael J. Yaeger. "Comparison of two commercial ovine Campylobacter vaccines and an experimental bacterin in guinea pigs inoculated with Campylobacter jejuni." American journal of veterinary research 72, no. 6 (2011): 799-805. doi: <a href="https://doi.org/10.2460/ajvr.72.6.799">https://doi.org/10.2460/ajvr.72.6.799</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/177/
dc.identifier.articleid 1176
dc.identifier.contextkey 10856270
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/177
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92284
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/177/0-Zhang_AVMA_Permission.pdf|||Fri Jan 14 21:27:39 UTC 2022
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/177/2011_Zhang_ComparisonTwo.pdf|||Fri Jan 14 21:27:40 UTC 2022
dc.source.uri 10.2460/ajvr.72.6.799
dc.subject.disciplines Comparative and Laboratory Animal Medicine
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Comparison of two commercial ovine Campylobacter vaccines and an experimental bacterin in guinea pigs inoculated with Campylobacter jejuni
dc.type article
dc.type.genre article
dspace.entity.type Publication
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