Direct Synthesis of Chrysosplenol D

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2008-10-15
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Roy, Sudipta
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Kraus, George
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Chemistry

The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).

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The Department of Chemistry was founded in 1880.

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1880-present

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Abstract

An aldol condensation and an Algar−Flynn−Oyamada oxidative cyclization were key steps in the direct synthesis of chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.

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Reprinted (adapted) with permission from Journal of Natural Products, 71(11); 1961-1962. Doi: 10.1021/np800423j. Copyright 2008 American Chemical Society.

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Tue Jan 01 00:00:00 UTC 2008
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