Genetic Parameters and Genomic Regions Associated with Growth Rate and Response to Newcastle Disease in Local Chicken Ecotypes in Ghana and Tanzania

dc.contributor.author Amuzu-Aweh, Esinam
dc.contributor.author Walugembe, Muhammed
dc.contributor.author Kayang, Boniface
dc.contributor.author Muhairwa, Amandus
dc.date 2018-08-25T21:37:04.000
dc.date.accessioned 2020-06-29T23:37:44Z
dc.date.available 2020-06-29T23:37:44Z
dc.date.copyright Mon Jan 01 00:00:00 UTC 2018
dc.date.issued 2018-01-01
dc.description.abstract <p>Local chicken enterprises in Africa are of great importance to household livelihoods but face major constraints with devastating disease outbreaks such as Newcastle disease (ND), which cause major economic losses. A study was conducted in two countries, Ghana and Tanzania, where three ecotypes in each country were challenged with a lentogenic (vaccine) strain of ND virus and various response phenotypes, including growth, anti-NDV antibody levels, and viral load from hatch to 38 days of age were taken. We estimated variance components and performed a genome-wide association study (GWAS) using ~2800 birds. Moderate heritabilities (0.14-0.55) of the above traits indicated that selection to improve these breeds/ecotypes for resistance to ND could be feasible. Genome-wide association analyses revealed several genomic regions that explained more than 0.5% of the genetic variance, including a candidate gene region for antibody response on chromosome 1. Future studies will characterize differences between the breeds/ecotypes, determine if large breed-specific quantitative trait loci can be identified, and evaluate the response of the same birds to endemic, velogenic ND virus strains.</p>
dc.identifier archive/lib.dr.iastate.edu/ans_air/vol664/iss1/58/
dc.identifier.articleid 2373
dc.identifier.contextkey 11706097
dc.identifier.doi https://doi.org/10.31274/ans_air-180814-376
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ans_air/vol664/iss1/58
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/9434
dc.language.iso en
dc.relation.ispartofseries Animal Science Research Reports
dc.relation.ispartofseries ASL R3260
dc.source.bitstream archive/lib.dr.iastate.edu/ans_air/vol664/iss1/58/R3260.pdf|||Sat Jan 15 01:01:23 UTC 2022
dc.subject.disciplines Poultry or Avian Science
dc.title Genetic Parameters and Genomic Regions Associated with Growth Rate and Response to Newcastle Disease in Local Chicken Ecotypes in Ghana and Tanzania
dc.type article
dc.type.genre poultry
dspace.entity.type Publication
relation.isJournalIssueOfPublication 296e1300-1e03-4007-b87f-b55a83478559
relation.isSeriesOfPublication 7f3839b7-b833-4418-a6fa-adda2b23950a
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