Morphological effects of Pasteurella multocida Type-D dermonecrotoxin on rat osteosarcoma cells in a nude mouse model Ackermann, Mark Dyer, N. Haynes, Joseph Ackermann, Mark Haynes, Joseph Rimler, R.
dc.contributor.department Veterinary Pathology 2018-02-13T06:27:36.000 2020-07-07T05:15:57Z 2020-07-07T05:15:57Z 2013-02-27 1998-08-01
dc.description.abstract <p><p id="x-x-">Of 15 athymic nude mice that received subcutaneous implants of a rat osteosarcoma cell line, two groups of four subsequently received either a short (group 1) or a more prolonged (group 2) course of subcutaneous injections of the dermonecrotic toxin (DNT) of <em>Pasteurella multocida</em> type D. The remaining seven mice (controls) received no DNT. Both groups of DNT-treated mice lost body weight as compared with controls. Tumour weight, expressed as a percentage of body weight, increased in the four group 1 mice, Tumours in this group 1 were consistently larger than those in appropriate controls, indicating that this percentage was not simply a function of decreased body weight. The immunohistochemical labelling of proliferating cell nuclear antigen (PCNA) and morphometric analysis of intratumoral necrosis suggested that the DNT had a mitogenic effect and contributed to the neoplastic growth. The presence of foci of neoplastic osteoblasts in the lungs of some DNT-treated mice suggested that the enhanced tumour growth led to an increased incidence of metastasis.</p>
dc.description.comments <p>This article is from <em>Journal of Comparative Pathology </em>119, no. 2 (August 1998): 149–158, doi:<a href="" id="x-ddDoi" target="_blank">10.1016/S0021-9975(98)80059-5</a>.</p>
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dc.identifier.articleid 1049
dc.identifier.contextkey 3801003
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dc.language.iso en
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dc.source.uri 10.1016/S0021-9975(98)80059-5
dc.subject.disciplines Veterinary Pathology and Pathobiology
dc.title Morphological effects of Pasteurella multocida Type-D dermonecrotoxin on rat osteosarcoma cells in a nude mouse model
dc.type article
dc.type.genre article
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