Self-Immolative Phthalate Esters Sensitive to Hydrogen Peroxide and Light

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2014-11-10
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Mahoney, Kaitlyn
Goswami, Pratik
Ayed, Aleem
Kolker, Patrick
Shannan, Brian
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Smith, Emily
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Winter, Arthur
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Chemistry

The Department of Chemistry seeks to provide students with a foundation in the fundamentals and application of chemical theories and processes of the lab. Thus prepared they me pursue careers as teachers, industry supervisors, or research chemists in a variety of domains (governmental, academic, etc).

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Abstract

Self-immolative aryl phthalate esters were conjugated with cleavable masking groups sensitive to light and hydrogen peroxide. The phthalate linker releases the fluorescent dye 7-hydroxycoumarin upon exposure to light or H2O2, respectively, leading to an increase in fluorescence. The light-sensitive aryl phthalate ester is demonstrated as a pro- fluorophore in cultured S2 cells

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Reprinted (adapted) with permission from The Journal of Organic Chemistry, 79(23); 11740-11743. Doi: 10.1021/jo501900h. Copyright 2014 American Chemical Society.

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Wed Jan 01 00:00:00 UTC 2014
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