Artificial enzyme for Henry and Retro-Henry reactions

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2023-08
Authors
Ilyas, Iqra
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Zhao, Yan
Stanley, Levi
Huang, Wenyu
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Chemistry
Abstract
Owing to their specificity and substrate selectivity, molecularly imprinted nanoparticles (MINPs) have been used to overcome many challenges associated with natural enzymes such as their instability under harsh pH and temperature and traditional artificial enzymes that have poor catalytic efficiency. MINPs are synthesized from doubly cross linkable surfactants in the presence of templates and appropriate functional monomers. They contain template complementary binding sites. These resulting nanoparticles are water soluble and similar to protein in size, making them suitable for biological applications. In addition to their utility in glycan recognition, hydrolysis of cellulose and catalyzing other reactions, MINPs also provides us with the opportunity to explore their ability to catalyze Retro-Henry reaction which is performed by natural enzymes and is important in obtaining stereo chemically pure asymmetrical nitro alcohols.
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