Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens

dc.contributor.author Bartholomay, Lyric
dc.contributor.author Waterhouse, Robert
dc.contributor.author Mayhew, George
dc.contributor.author Campbell, Corey
dc.contributor.author Michel, Kristin
dc.contributor.author Zou, Zhen
dc.contributor.author Ramirez, Jose
dc.contributor.author Das, Suchismita
dc.contributor.author Alvarez, Kanwal
dc.contributor.author Arensburger, Peter
dc.contributor.author Bryant, Bart
dc.contributor.author Chapman, Sinead
dc.contributor.author Dong, Yuemei
dc.contributor.author M., Erickson
dc.contributor.author Karunaratne, S.H.P.
dc.contributor.author Kokoza, Vladimir
dc.contributor.author Kodira, Chinnappa
dc.contributor.author Pignatelli, Patricia
dc.contributor.author Shin, Sang
dc.contributor.author Vanlandingham, Dana
dc.contributor.author Atkinson, Peter
dc.contributor.author Birren, Bruce
dc.contributor.author Christophides, Geoge
dc.contributor.author Clem, Rollie
dc.contributor.author Hemingway, Janet
dc.contributor.author Higgs, Stephen
dc.contributor.author Megy, Karine
dc.contributor.author Ranson, Hilary
dc.contributor.author Zdobnov, Evgeny
dc.contributor.author Raikhel, Alexander
dc.contributor.author Christensen, Bruce
dc.contributor.author Dimopoulos, George
dc.contributor.author Muskavitch, Marc
dc.contributor.department Entomology
dc.date 2018-02-14T13:31:52.000
dc.date.accessioned 2020-06-30T02:22:04Z
dc.date.available 2020-06-30T02:22:04Z
dc.date.copyright Fri Jan 01 00:00:00 UTC 2010
dc.date.embargo 2014-09-08
dc.date.issued 2010-01-01
dc.description.abstract <p>The mosquito <em>Culex quinquefasciatus</em> poses a significant threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm <em>Wuchereria bancrofti</em>, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical <em>C. quinquefasciatus</em> immune gene repertoire compared with those of <em>Aedes aegypti</em> and <em>Anopheles gambiae</em>. Transcriptomic analysis of <em>C. quinquefasciatus</em> genes responsive to WNV, <em>W. bancrofti</em> and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.</p>
dc.description.comments <p>This is an author's manuscript of an article from <em>Science</em> 330 (2010): 88, <a href="http://dx.doi.org/10.1126/science.1193162" target="_blank">doi:10.1126/science.1193162</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/ent_pubs/160/
dc.identifier.articleid 1142
dc.identifier.contextkey 6090852
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ent_pubs/160
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/23763
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/ent_pubs/160/2010_Bartholomay_PathogenomicsCulex.pdf|||Fri Jan 14 20:53:29 UTC 2022
dc.source.uri 10.1126/science.1193162
dc.subject.disciplines Entomology
dc.subject.disciplines Infectious Disease
dc.subject.disciplines Medical Biochemistry
dc.subject.disciplines Virus Diseases
dc.title Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isOrgUnitOfPublication f47c8cad-50be-4fb0-8870-902ff536748c
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