Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens Bartholomay, Lyric Waterhouse, Robert Mayhew, George Campbell, Corey Michel, Kristin Zou, Zhen Ramirez, Jose Das, Suchismita Alvarez, Kanwal Arensburger, Peter Bryant, Bart Chapman, Sinead Dong, Yuemei M., Erickson Karunaratne, S.H.P. Kokoza, Vladimir Kodira, Chinnappa Pignatelli, Patricia Shin, Sang Vanlandingham, Dana Atkinson, Peter Birren, Bruce Christophides, Geoge Clem, Rollie Hemingway, Janet Higgs, Stephen Megy, Karine Ranson, Hilary Zdobnov, Evgeny Raikhel, Alexander Christensen, Bruce Dimopoulos, George Muskavitch, Marc
dc.contributor.department Entomology 2018-02-14T13:31:52.000 2020-06-30T02:22:04Z 2020-06-30T02:22:04Z Fri Jan 01 00:00:00 UTC 2010 2014-09-08 2010-01-01
dc.description.abstract <p>The mosquito <em>Culex quinquefasciatus</em> poses a significant threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm <em>Wuchereria bancrofti</em>, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical <em>C. quinquefasciatus</em> immune gene repertoire compared with those of <em>Aedes aegypti</em> and <em>Anopheles gambiae</em>. Transcriptomic analysis of <em>C. quinquefasciatus</em> genes responsive to WNV, <em>W. bancrofti</em> and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.</p>
dc.description.comments <p>This is an author's manuscript of an article from <em>Science</em> 330 (2010): 88, <a href="" target="_blank">doi:10.1126/science.1193162</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/
dc.identifier.articleid 1142
dc.identifier.contextkey 6090852
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath ent_pubs/160
dc.language.iso en
dc.source.bitstream archive/|||Fri Jan 14 20:53:29 UTC 2022
dc.source.uri 10.1126/science.1193162
dc.subject.disciplines Entomology
dc.subject.disciplines Infectious Disease
dc.subject.disciplines Medical Biochemistry
dc.subject.disciplines Virus Diseases
dc.title Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isOrgUnitOfPublication f47c8cad-50be-4fb0-8870-902ff536748c
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
123.24 KB
Adobe Portable Document Format