Hogs are often grown in close proximity to turkey farms in North Cartolina, and the potential exists for transfer of pathogens, including Campylobacter, from one host animal to another. The aim of this study was to obtain evidence for possible transfer of Campylobacter coli from hogs to turkeys, or vice versa. Strains from four paired hog and turkey farms were isolated and characterized in terms of their antibiotic resistance profiles, and by molecular subtyping utilizing PCR-RFLP of flaA. Certain strains were found to be shared between hogs and turkeys, suggesting possible transfer. In spite of identical molecular subtypes, such strains commonly differed in antibiotic resistance profiles. The results are consistent with the hypothesis that strains of C. coli may transfer between hogs and turkeys, or that certain strain subtypes may independently colonize these animals through unidentified reservoirs.