TLR4 Single Nucleotide Polymorphisms (SNPs) Associated with Salmonella Shedding in Pigs

Date
2013-01-01
Authors
Kich, Jalusa
Uthe, Joliat
Benavides, Magda
Cantão, Maurício
Zanella, Ricardo
Tuggle, Christopher
Bearson, Shawn
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Abstract

Toll-like receptor 4 (TLR4) is a key factor in the innate immune recognition of lipopolysaccharide (LPS) from Gram-negative bacteria. Previous studies from our group identified differences in the expression profile of TLR4 and genes affected by the TLR4 signaling pathway among pigs that shed varying levels of Salmonella, a Gram-negative bacterium. Therefore, genetic variation in this gene may be involved with the host’s immune response to bacterial infections. The current study screened for single nucleotide polymorphisms (SNPs) in the TLR4 gene and tested their association with Salmonella fecal shedding.

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