Heat stress alters animal physiology and post-absorptive metabolism during pre- and postnatal development

dc.contributor.advisor Lance H. Baumgard
dc.contributor.author Johnson, Jay
dc.contributor.department Animal Science
dc.date 2018-08-11T11:10:58.000
dc.date.accessioned 2020-06-30T02:53:32Z
dc.date.available 2020-06-30T02:53:32Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2014
dc.date.embargo 2015-07-30
dc.date.issued 2014-01-01
dc.description.abstract <p>Heat stress (HS) is a key limiting factor to efficient animal production and negatively impacts health and development during postnatal life. In addition, hyperthermia during in utero development can permanently alter postnatal phenotypes and negatively impact future animal performance. While the teratogenic effects of prenatal HS have been extensively evaluated, the impact of in utero HS exposure on future mammalian thermoregulation, nutrient partitioning, and bioenergetics is undefined. To determine the postnatal consequences of in utero HS, pregnant first parity sows and rats were exposed to either thermal neutral (TN) or HS conditions for the entire gestation, the first half, or second half of gestation. To account for differences in maternal nutrient intake, we utilized an ad libitum TN control group and a pair-fed TN control group of rats. Progeny were evaluated for differences in production performance, nutrient partitioning, thermoregulation, and post-absorptive metabolism. In a series of experiments, it was determined that prenatal HS exposure increased postnatal adipose deposition at the expense of skeletal muscle mass and permanently increased core body temperature during future development. When compared with in utero HS-exposed rats, pair-fed TN exposed progeny had increased adipose tissue and reduced lean tissue mass. In opposition to some previously published reports, postnatal HS exposure seems to reduce maintenance costs, which may have implications toward energy efficiency during times of thermal stress. In summary, HS modifies animal metabolism and physiology during both pre- and postnatal development and reduces livestock production efficiency.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/etd/13982/
dc.identifier.articleid 4989
dc.identifier.contextkey 6199708
dc.identifier.doi https://doi.org/10.31274/etd-180810-3204
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath etd/13982
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/28169
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/etd/13982/Johnson_iastate_0097E_14396.pdf|||Fri Jan 14 20:05:13 UTC 2022
dc.subject.disciplines Agriculture
dc.subject.disciplines Animal Sciences
dc.subject.disciplines Human and Clinical Nutrition
dc.subject.disciplines Nutrition
dc.subject.disciplines Physiology
dc.subject.keywords Bioenergetics
dc.subject.keywords Body composition
dc.subject.keywords Heat Stress
dc.subject.keywords In utero stress
dc.subject.keywords Metabolism
dc.subject.keywords Thermoregulation
dc.title Heat stress alters animal physiology and post-absorptive metabolism during pre- and postnatal development
dc.type article
dc.type.genre dissertation
dspace.entity.type Publication
relation.isOrgUnitOfPublication 85ecce08-311a-441b-9c4d-ee2a3569506f
thesis.degree.level dissertation
thesis.degree.name Doctor of Philosophy
Original bundle
Now showing 1 - 1 of 1
2.12 MB
Adobe Portable Document Format