Evaluation of the Onset of Protective Immunity from Administration of a Modified-live, Non-adjuvanted Vaccine prior to Intranasal Challenge with Bovine Herpesvirus-1

dc.contributor.author Burdett, William
dc.contributor.author Bolton, Michael
dc.contributor.author Roth, James
dc.contributor.author Kesl, Lyle
dc.contributor.author Nordstrom, Scott
dc.contributor.author Renter, David
dc.contributor.author Roth, James
dc.contributor.author Saltzman, Ryan
dc.contributor.author Xue, Wenzhi
dc.contributor.department Veterinary Microbiology and Preventive Medicine
dc.date 2018-02-17T05:03:08.000
dc.date.accessioned 2020-07-07T05:15:32Z
dc.date.available 2020-07-07T05:15:32Z
dc.date.copyright Sat Jan 01 00:00:00 UTC 2011
dc.date.issued 2011-04-01
dc.description.abstract <p>Study objectives were to determine if subcutaneous administration of a modified-live, non-adjuvanted vaccine containing bovine herpesvirus-1 (BHV-1) at five, three, or two days pre-challenge, would reduce clinical signs, rectal temperatures, and viral shedding, and enhance serological response to BHV-1. Colostrumdeprived, neonatal calves (n = 48) were randomly assigned to six treatment groups, each containing eight calves. Treatment groups were based on administration of vaccine (VAC) or saline controls (CON) and day of administration (day -5, -3 or -2) relative to intranasal BHV-1 challenge (day 0). Following challenge, calves were monitored for clinical signs, rectal temperature, seroconversion, and quantity of BHV-1 recovered by virus isolation from nasal swabs. Data for the evaluation period (days 4-14) were analyzed using multivariable statistics. Day -5 and -3 VAC groups had fewer (P < 0.05) days of clinical illness compared to CON. Rectal temperatures were lower (P < 0.05) during days 4-8 for each of the VAC groups as compared to combined CON groups. CON calves shed BHV-1 for more days than calves vaccinated on day -5 (P < 0.01), day -3 (P = 0.06), or day -2 (P = 0.06). Mean concentrations of nasal BHV-1 also differed (P < 0.05) between combined CON groups and each of the VAC groups during at least one study day. Calves in the VAC groups (median = 10 days) seroconverted to BHV-1 (P < 0.01) sooner than CON calves (median = 14 days). This study demonstrated that the use of a non-adjuvanted MLV vaccine in neonatal calves can reduce the effects of BHV-1 challenge soon after vaccination.</p>
dc.description.comments <p>This article is from <em>The Bovine Practitioner</em> 45 (2011): 32. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vmpm_pubs/93/
dc.identifier.articleid 1090
dc.identifier.contextkey 7807161
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vmpm_pubs/93
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/92403
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vmpm_pubs/93/2011_Roth_EvaluationOnset.pdf|||Sat Jan 15 02:31:06 UTC 2022
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.subject.keywords BHV-1
dc.subject.keywords IBR
dc.subject.keywords vaccine
dc.subject.keywords immunity challenge studies
dc.title Evaluation of the Onset of Protective Immunity from Administration of a Modified-live, Non-adjuvanted Vaccine prior to Intranasal Challenge with Bovine Herpesvirus-1
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 909dd0b2-ec0a-41e2-b4e0-9e5ff76b7622
relation.isOrgUnitOfPublication 16f8e472-b1cd-4d8f-b016-09e96dbc4d83
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