The effects of stress on working memory, inhibitory gating, and motor symptoms in Parkinson’s disease

dc.contributor.advisor Elizabeth Stegemöller Zaman, Andrew
dc.contributor.department Kinesiology 2020-09-23T19:12:42.000 2021-02-25T21:37:16Z 2021-02-25T21:37:16Z Sat Aug 01 00:00:00 UTC 2020 2020-09-10 2020-01-01
dc.description.abstract <p>Parkinson's disease (PD) is a neurodegenerative disorder in which the substantia nigra has suffered a severe amount of cell loss, resulting in basal ganglia dysfunction. The defining motor symptoms of PD are tremor, rigidity (stiffness of the limbs and trunk), bradykinesia (slow movements), and postural instability (impaired balance). Persons with PD also have a number of non-motor symptoms such as anxiety, depression, autonomic dysfunction, cognitive impairment, and deficits in sensory processing. Currently, there is a gap in our knowledge about how stress affects persons with PD. Anecdotally, many people with PD report that their symptoms get worse when they are stressed. However, there is only indirect and anecdotal evidence for persons with PD. Thus, the purpose of this study was to examine how stress affects motor and non-motor symptoms in persons with PD.</p> <p>Fifteen persons with PD and fifteen healthy older adults were recruited for the study. We measured how an acute stressor (socially evaluated cold pressor) affected working memory (digit span tasks), sensory processing (inhibitory gating), and PD motor symptoms (UPDRS motor tests). Results showed that stress appears to have differential effects in persons with PD. In persons with PD, stress negatively impacted inhibitory gating and PD motor symptoms. However, stress had positive effects on working memory. The results also suggest that inhibitory gating is associated with PD motor symptom severity, and, thus, inhibitory gating may be a potential therapeutic target. This research provides a first step in understanding how stress impacts persons with PD. Overall, the work of this dissertation suggests that acute stress is a useful tool in understanding PD, and that stress management may be an effective therapy for managing PD motor symptoms.</p>
dc.format.mimetype application/pdf
dc.identifier archive/
dc.identifier.articleid 9260
dc.identifier.contextkey 19236855
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath etd/18253
dc.language.iso en
dc.source.bitstream archive/|||Fri Jan 14 21:39:12 UTC 2022
dc.subject.keywords Inhbitory Gating
dc.subject.keywords Motor Symptoms
dc.subject.keywords Parkinson's
dc.subject.keywords Stress
dc.subject.keywords UPDRS
dc.subject.keywords Working Memory
dc.title The effects of stress on working memory, inhibitory gating, and motor symptoms in Parkinson’s disease
dc.type article
dc.type.genre dissertation
dspace.entity.type Publication
relation.isOrgUnitOfPublication f7b0f2ca-8e43-4084-8a10-75f62e5199dd Kinesiology; Psychology dissertation Doctor of Philosophy
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