Associations of the porcine immune response and genetic polymorphisms with the shedding of Salmonella enterica serovar Typhimurium

Date
2007-01-01
Authors
Bearson, S.
Uthe, J.
Wang, Y.
Qu, L.
Dekkers, J.
Nettleton, D.
Bearson, B.
Tuggle, C.
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Altmetrics
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Abstract

A major focus of our collaborattve research is to investigate the porctne response to Infection with Salmonella to 1) identify porctne genes differentially regulated during Infection and 2) Identify and associate genetic polymorphisms within these genes with infection status across swine populations In the current study, 40 crossbred pigs were intranasally inoculated with Salmonella enterica serovar Typhimurium and monitored for Salmonella fecal shedding and blood 1mmune parameters at 2, 7, 14 and 20 days post-inoculation (dpi). Using a multivariate permutation test, a positive correlation was observed between Salmonella shedding and Interferon-gamma (IFNG) levels at 2 and 7 dpi (p<0.05), with a greater number of Salmonella shedding 1n the animals with higher IFNG levels.

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Animal Science
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