Investigation of the efficacy of a genetically-stabile live Salmonella typhimurium vaccine for use in swine

dc.contributor.author Springer, Sven
dc.contributor.author Lindner, Thomas
dc.contributor.author Steinbach, Günther
dc.contributor.author Selbitz, Hans-Joachim
dc.date 2018-08-13T20:07:04.000
dc.date.accessioned 2020-07-02T06:18:47Z
dc.date.available 2020-07-02T06:18:47Z
dc.date.issued 2001-01-01
dc.description.abstract <p>Hybrid swine were immunized twice at an interval of 3 weeks to evaluate the efficacy of a liveS. typhimurium vaccine. The animals and a control group were challenged at the age of 8-10 weeks by oral test infection with a labelled S. typhimurium DT l 04 strain. An ELISA was used to establish the presence of antibodies to S. typhimurium in serum samples. The presence of the challenge strain in the ileal and caecal mucosa and in the ileocolic lymph nodes was investigated quantitatively using the Koch plating method. The vaccinated animals had significantly higher antibody titres after the second vaccination than the unvaccinated animals. The vaccinated animals had a significantly lower (p < 0.05) colonization of the ileal and caecal mucosa as well as the ileocolic lymph nodes than the unvaccinated animals.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/safepork/2001/allpapers/19/
dc.identifier.articleid 2037
dc.identifier.contextkey 6220262
dc.identifier.doi https://doi.org/10.31274/safepork-180809-1072
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath safepork/2001/allpapers/19
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/83469
dc.language.iso en
dc.relation.ispartofseries International Conference on the Epidemiology and Control of Biological, Chemical and Physical Hazards in Pigs and Pork
dc.source.bitstream archive/lib.dr.iastate.edu/safepork/2001/allpapers/19/2001_SpringerS_InvestigationEfficacyGenetically.pdf|||Fri Jan 14 21:49:04 UTC 2022
dc.subject.disciplines Animal Diseases
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.disciplines Veterinary Preventive Medicine, Epidemiology, and Public Health
dc.title Investigation of the efficacy of a genetically-stabile live Salmonella typhimurium vaccine for use in swine
dc.type event
dc.type.genre article
dspace.entity.type Publication
relation.isSeriesOfPublication aab46b45-e596-479d-af7f-e072b1599cd7
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