Induction of resistant mutants of Salmonella typhimurium under enrofloxacin and natural alternatives for control in pigs
de Aguiar, Fabiana
The increase in bacterial resistance to Enrofloxacin (ENR) in recent years has been associated with the selective growth of single-step mutant strains resistant to the frequent dose in use, based on the Minimum Inhibitory Concentration (MIC). Because of that, it is supported the need to establish optimal dosage intervals taking into account the minimum concentration of antibiotic capable of inhibiting the growth of pre-existing or first pass mutant strains: Mutant Prevention Concentration (MPC). Therefore, it is of importance to maintain the antimicrobial and molecular monitoring of quinolones and to search for new alternatives, such as the use of essential oils for the control of salmonellosis.