A microelectrode device to investigate the effect of electrical stimulation on neural progenitor cell growth, alignment, and differentiation

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dc.contributor.author Todd, Michael
dc.contributor.department Theses & dissertations (Interdisciplinary)
dc.date 2020-11-09T01:33:07.000
dc.date.accessioned 2021-02-26T09:01:11Z
dc.date.available 2021-02-26T09:01:11Z
dc.date.copyright Sat Jan 01 00:00:00 UTC 2005
dc.date.issued 2005-01-01
dc.description.abstract <p>A polyimide-based, biocompatible microelectrode device has been designed, fabricated, and tested. The microelectrode device is multilayered, with pairs of microelectrodes positioned underneath microgrooves. The substrate has been designed to enable cells to align along the microgrooves and then be selectively stimulated using particular pairs of microelectrodes. This design might enable the substrates to be used in a conduit to replace damage optic nerves with selective stimulation of cells based on signals received from devices such as a retinal chip. The microelectrode devices also serve as model devices to investigate the effect of electrical stimulation in conjunction with various physical and chemical cues on the growth and differentiation of neural progenitor cells (NPC) in vitro. This device has been used to electrically and physically stimulate individual neural progenitor cells to investigate the effect of electrical stimulation on NPC growth, alignment, and differentiation. In the future this microelectrode device may be used to selectively record signals from cells.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/rtd/20959/
dc.identifier.articleid 21958
dc.identifier.contextkey 20115431
dc.identifier.doi https://doi.org/10.31274/rtd-20201107-516
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath rtd/20959
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/98326
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/rtd/20959/Todd_ISU_2005_T63.pdf|||Fri Jan 14 22:30:47 UTC 2022
dc.subject.keywords Neuroscience
dc.title A microelectrode device to investigate the effect of electrical stimulation on neural progenitor cell growth, alignment, and differentiation
dc.type article
dc.type.genre thesis
dspace.entity.type Publication
thesis.degree.discipline Neuroscience
thesis.degree.level thesis
thesis.degree.name Master of Science
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