Comparison of Mycoplasma hyopneumoniae response to infection by route of exposure

dc.contributor.author Linhares, Daniel
dc.contributor.author Poeta Silva, Ana Paula S.
dc.contributor.author Marostica, Thaire
dc.contributor.author McDaniel, Aric
dc.contributor.author Karriker, Locke
dc.contributor.author Arruda, Bailey
dc.contributor.author Alonso, Carmen
dc.contributor.author Derscheid, Rachel
dc.contributor.author Yeske, Paul
dc.contributor.author Linhares, Daniel
dc.contributor.author Giménez-Lirola, Luis
dc.contributor.author Karriker, Locke
dc.contributor.author Fano, Eduardo
dc.contributor.author Zimmerman, Jeffrey
dc.contributor.author Clavijo, Maria
dc.contributor.author Giménez-Lirola, Luis
dc.contributor.department Veterinary Diagnostic and Production Animal Medicine
dc.date 2021-05-21T01:36:34.000
dc.date.accessioned 2021-08-15T02:05:13Z
dc.date.available 2021-08-15T02:05:13Z
dc.date.copyright Fri Jan 01 00:00:00 UTC 2021
dc.date.issued 2021-05-15
dc.description.abstract <p><em>Mycoplasma hyopneumoniae</em> (<em>MHP</em>) is a concern both for pig well-being and producer economic viability. In the absence of fully protective health interventions, producers rely on controlled exposure to induce an immune response in pigs and minimize the clinical outcomes of <em>MHP</em> infection in pig populations. This study compared the effect of route of exposure on <em>MHP</em> infection, antibody response, clinical signs, and pathology. Six-week-old <em>MHP</em>-negative pigs (n = 78) were allocated to negative control (n = 6) or one of three <em>MHP</em> exposure routes: intratracheal (n = 24, feeding catheter), intranasal (n = 24, atomization device), and aerosol (n = 24, fogger). Body weight, cough indices, and samples (serum, oral fluid, tracheal) were collected weekly through 49 days post-exposure (DPE). Intratrachal exposure produced the highest proportion (24/24) of <em>MHP</em> DNA-positive pigs on DPE 7, as well as earlier and higher serum antibody response. Intranasal and aerosol exposures resulted in infection with <em>MHP</em> DNA detected in tracheal samples from 18/24 and 21/24 pigs on DPE 7, respectively. Aerosol exposure had the least impact on weight gain (0.64 kg/day). No difference was observed among treatment groups in coughing and lung lesions at necropsy. While intratracheal inoculation or the use of seeder animals are frequently used in swine production settings, intranasal or aerosol exposure are viable alternatives to achieve infection. Regardless of the route, steps should be taken to verify the purity of the inoculum and, in the case of aerosol exposure, avert the unintended exposure of personnel and animals to other pathogens.</p>
dc.description.comments <p>This is a manuscript of an article published as Silva, Ana Paula S. Poeta, Thaire P. Marostica, Aric McDaniel, Bailey L. Arruda, Carmen Alonso, Rachel Derscheid, Paul Yeske et al. "Comparison of Mycoplasma hyopneumoniae response to infection by route of exposure." <em>Veterinary Microbiology</em> (2021): 109118. DOI: <a href="https://doi.org/10.1016/j.vetmic.2021.109118" target="_blank">10.1016/j.vetmic.2021.109118</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/vdpam_pubs/209/
dc.identifier.articleid 1213
dc.identifier.contextkey 23017488
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath vdpam_pubs/209
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/4vGXkWNr
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/vdpam_pubs/209/2021_LinharesDaniel_ComparisonMycoplasma.pdf|||Fri Jan 14 22:30:11 UTC 2022
dc.source.uri 10.1016/j.vetmic.2021.109118
dc.subject.disciplines Large or Food Animal and Equine Medicine
dc.subject.disciplines Veterinary Infectious Diseases
dc.subject.disciplines Veterinary Microbiology and Immunobiology
dc.subject.keywords intratracheal
dc.subject.keywords intranasal
dc.subject.keywords aerosol
dc.subject.keywords exposure
dc.subject.keywords flow rate
dc.subject.keywords oral fluids
dc.title Comparison of Mycoplasma hyopneumoniae response to infection by route of exposure
dc.type article
dc.type.genre article
dspace.entity.type Publication
relation.isAuthorOfPublication 3ce0db9e-1f42-4d29-b389-2364b3470254
relation.isAuthorOfPublication cdddf686-265a-41eb-9374-c5ff25e5120d
relation.isAuthorOfPublication abbf44fd-a4a0-4859-8b5c-af2b853c9547
relation.isOrgUnitOfPublication 5ab07352-4171-4f53-bbd7-ac5d616f7aa8
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