Effects of a periosteal activation agent on bone repair, bone growth, and bone ingrowth into a porous material in the rabbit

dc.contributor.author	Alberts, L.
dc.contributor.department	Chemical and Biological Engineering
dc.date	2018-08-15T20:14:24.000
dc.date.accessioned	2020-07-02T05:57:55Z
dc.date.available	2020-07-02T05:57:55Z
dc.date.copyright	Fri Jan 01 00:00:00 UTC 1982
dc.date.issued	1982
dc.description.abstract	<p>A periosteal activation agent (PAA) known to activate the cambium layer of the resting periosteum was applied to the femurs of rabbits for three cases of interest: (1) its effect on the healing of a circular defect in the femur, (2) its effect on bone ingrowth into a porous implant, and (3) its effect on formation of bone along the endosteal surface of the femur. In the first two cases, PAA was applied to the periosteal surface of the diaphyses of the femurs seven days after surgery at an optimal dosage of 400 mg per kg of body weight. In the empty defect series, two holes, 4 mm in diameter, were drilled through one cortex of each femur. In the implant series, two cylindrical porous implants of high density polyethylene (average pore size of 127 (mu)m and 4 mm in diameter) were implanted in one cortex of each femur. In the endosteal activation series, PAA was applied along the endosteal surface of the femurs at a dosage of 100 mg per kg of body weight (a level chosen to assure rabbit survival) through a hole bored through the trochanter fosse. The contralateral femurs served as controls in all cases;The endosteal activation series showed that PAA enhanced the natural periosteal callus formation elicited by the surgical trauma at 1 (p < .05), 3, 5 (p < .05), 7, 10 (p < .05), and 14 days, but it did not show any enhanced healing of the defect. The implant series also showed enhanced callus formation at 1 (p < .05), 3, 7, 10, and 14 days after application of PAA, but it failed to show any enhanced bone ingrowth into the interstices of the implant. The results of the endosteal activation series were inconclusive. In certain cases, larger amounts of new bone were observed; however, there was great rabbit-to-rabbit variability in the response. Possible reasons for this include the difficulty of administering the PAA to a local endosteal region of interest without causing excessive trauma to the general area of the medullary canal.</p>
dc.format.mimetype	application/pdf
dc.identifier	archive/lib.dr.iastate.edu/rtd/7019/
dc.identifier.articleid	8018
dc.identifier.contextkey	6304170
dc.identifier.doi	https://doi.org/10.31274/rtd-180813-6385
dc.identifier.s3bucket	isulib-bepress-aws-west
dc.identifier.submissionpath	rtd/7019
dc.identifier.uri	https://dr.lib.iastate.edu/handle/20.500.12876/79850
dc.language.iso	en
dc.source.bitstream	archive/lib.dr.iastate.edu/rtd/7019/r_8221166.pdf\|\|\|Sat Jan 15 01:40:53 UTC 2022
dc.subject.disciplines	Biomedical Engineering and Bioengineering
dc.subject.keywords	Biomedical engineering
dc.subject.keywords	Engineering science and mechanics
dc.subject.keywords	Engineering mechanics
dc.title	Effects of a periosteal activation agent on bone repair, bone growth, and bone ingrowth into a porous material in the rabbit
dc.type	article
dc.type.genre	dissertation
dspace.entity.type	Publication
relation.isOrgUnitOfPublication	86545861-382c-4c15-8c52-eb8e9afe6b75
thesis.degree.level	dissertation
thesis.degree.name	Doctor of Philosophy

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