Manufacturing of poly(ethylene glycol diacrylate)-based hollow microvessels using microfluidics

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2020-01-24
Authors
Aykar, Saurabh
Reynolds, David
McNamara, Marilyn
Hashemi, Nicole
Hashemi, Nicole
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Ames Laboratory
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Biomedical Sciences
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Mechanical Engineering
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The microvasculature is a vital organ that distributes nutrients within tissues, and collects waste products from them, and which defines the environmental conditions in both normal and disease situations. Here, a microfluidic chip was developed for the fabrication of poly(ethylene glycol diacrylate) (PEGDA)-based hollow self-standing microvessels having inner dimensions ranging from 15 μm to 73 μm and displaying biocompatibility/cytocompatibility. Macromer solutions were hydrodynamically focused into a single microchannel to form a concentric flow regime, and were subsequently solidified through photopolymerization. This approach uniquely allowed the fabrication of hollow microvessels having a defined structure and integrity suitable for cell culturing.

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<p>This article is published as Aykar, Saurabh S., David E. Reynolds, Marilyn C. McNamara, and Nicole N. Hashemi. "Manufacturing of poly(ethylene glycol diacrylate)-based hollow microvessels using microfluidics." <em>RSC Advances</em> 10, no. 7 (2020): 4095-4102. DOI: <a href="http://dx.doi.org/10.1039/C9RA10264G" target="_blank">10.1039/C9RA10264G</a>. Posted with permission.</p>
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