Efforts to implement control programs for zoonotic pathogens at the farm level are ongoing. However, establishing control programs for pathogens that may derive from multiple food-animal sources and for which there are interventions at various levels of the food chain can be challenging. Prioritizing pathogens for control programs should be based on scientific evidence and transparent decision-making processes. As part of a larger project applying multi-criteria decision analysis for prioritizing pathogens, a systematic review of the literature is being conducted with initial focus on existing published research on the prevalence of 15 zoonotic pathogens in swine populations and in humans, as attributable to swine and pork, within the North American context.