By implementing interphase sub-models obtained form particle-resolved direct numerical simulation(PR-DNS), a new computer fluid dynamics(CFD) two-fluid model for gas-solid reacting system can be established and may well improve the predictive ability. We proved the validity of applying PR-DNS drag model, heat transfer model, pseudo-turbulent velocity fluctuation model and pseudo-turbulent heat flux model into two-fluid model. When applying these PR-DNS submodels into the biomass fast pyrolysis case, the simulated reactor performance and product yields would change while still keep the trend of previous results.