Aerosol-jet-printed graphene electrochemical histamine sensors for food safety monitoring

dc.contributor.author Gomes, Carmen
dc.contributor.author Claussen, Jonathan
dc.contributor.author Parate, Kshama
dc.contributor.author Pola, Cícero
dc.contributor.author Rangnekar, Sonal
dc.contributor.author Mendivelso-Perez, Deyny
dc.contributor.author Smith, Emily
dc.contributor.author Smith, Emily
dc.contributor.author Hersam, Mark
dc.contributor.author Gomes, Carmen
dc.contributor.author Claussen, Jonathan
dc.contributor.department Ames Laboratory
dc.contributor.department Mechanical Engineering
dc.contributor.department Food Science and Human Nutrition
dc.contributor.department Virtual Reality Applications Center
dc.contributor.department Chemistry
dc.contributor.department Agricultural and Biosystems Engineering
dc.date 2021-01-26T05:26:11.000
dc.date.accessioned 2021-02-26T03:16:21Z
dc.date.available 2021-02-26T03:16:21Z
dc.date.copyright Wed Jan 01 00:00:00 UTC 2020
dc.date.embargo 2021-06-10
dc.date.issued 2020-06-10
dc.description.abstract <p>Carbon nanomaterials such as graphene exhibit unique material properties including high electrical conductivity, surface area, and biocompatibility that have the potential to significantly improve the performance of electrochemical sensors. Since in-field electrochemical sensors are typically disposable, they require materials that are amenable to low-cost, high-throughput, and scalable manufacturing. Conventional graphene devices based on low-yield chemical vapor deposition techniques are too expensive for such applications, while low-cost alternatives such as screen and inkjet printing do not possess sufficient control over electrode geometry to achieve favorable electrochemical sensor performance. In this work, aerosol jet printing (AJP) is used to create high-resolution (~40 <em>μ</em>m line width) interdigitated electrodes (IDEs) on flexible substrates, which are then converted into histamine sensors by covalently linking monoclonal antibodies to oxygen moieties created on the graphene surface through a CO2 thermal annealing process. The resulting electrochemical sensors exhibit a wide histamine sensing range of 6.25–200 ppm (56.25 <em>μ</em>M–1.8 mM) and a low detection limit of 3.41 ppm (30.7 <em>μ</em>M) within actual tuna broth samples. These sensor metrics are significant since histamine levels over 50 ppm in fish induce adverse health effects including severe allergic reactions (e.g. Scombroid food poisoning). Beyond the histamine case study presented here, the AJP and functionalization process can likely be generalized to a diverse range of sensing applications including environmental toxin detection, foodborne pathogen detection, wearable health monitoring, and health diagnostics.</p>
dc.description.comments <p>This is a peer-reviewed, un-copyedited version of an article accepted for publication/published in <em>2D Materials</em>. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at DOI: <a href="https://doi.org/10.1088/2053-1583/ab8919" target="_blank">10.1088/2053-1583/ab8919</a>. Posted with permission.</p>
dc.format.mimetype application/pdf
dc.identifier archive/lib.dr.iastate.edu/me_pubs/466/
dc.identifier.articleid 1464
dc.identifier.contextkey 21256833
dc.identifier.s3bucket isulib-bepress-aws-west
dc.identifier.submissionpath me_pubs/466
dc.identifier.uri https://dr.lib.iastate.edu/handle/20.500.12876/96703
dc.language.iso en
dc.source.bitstream archive/lib.dr.iastate.edu/me_pubs/466/2020_GomesCarmen_AerosolJet.pdf|||Sat Jan 15 00:23:47 UTC 2022
dc.source.uri 10.1088/2053-1583/ab8919
dc.subject.disciplines Acoustics, Dynamics, and Controls
dc.subject.disciplines Food Science
dc.subject.disciplines Materials Chemistry
dc.subject.disciplines Nanoscience and Nanotechnology
dc.subject.keywords graphene
dc.subject.keywords aerosol jet printing
dc.subject.keywords immunosensor
dc.subject.keywords interdigitated electrode
dc.subject.keywords electrochemical impedance spectroscopy
dc.subject.keywords food safety
dc.title Aerosol-jet-printed graphene electrochemical histamine sensors for food safety monitoring
dc.type article
dc.type.genre article
dspace.entity.type Publication
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